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Inflammatory Response after the Implantation of Bioresorbable Vascular Scaffolds vs. 2nd Generation Druh-eluting Stents
Novotný, Vojtěch ; Šťásek, Josef (advisor) ; Kala, Petr (referee) ; Kočka, Viktor (referee)
The concept of bioresorbable scaffolds (BVS) originated in the 90s of the 20th century, however, the first commercially available coronary BVS was Absorb BVS in 2011. The dissertation deals with aspects of working with this type of BVS and its use in real practice. We focused on examining the inflammatory response after implantation of Absorb BVS in comparison with the proven 2nd generation metallic drug eluting stent (DES). The introduction systematically discusses the topic of BVS from history, through the composition of BVS and implantation techniques to available literature data. The second topic discussed is the inflammatory response after coronary stent implantation, we provide an overview of available data from studies and the introduction of inflammatory markers, which were analyzed in the main study. The presented work includes three main studies. A Pilot study in which we evaluated the systemic inflammatory response to coronary artery trauma caused by percutaneous coronary intervention previously described in the literature. We verified that the selected laboratory-determined markers of systemic inflammation (hs-CRP, IL-6 and serum amyloid A) increase significantly 24/48 hours after PCI compared to basal. This pilot study was directly followed by the Randomized study, in which we randomly...
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Nursing Care of the Patient after Transcatheter Aortic Valve Implantation
Jamrich, Lukáš ; Vaňková, Milena (advisor) ; Kočka, Viktor (referee)
Resume This bachelor thesis is a case study of nursing care of 84-year-old patient hospitalised for aortic stenosis. The patient was treated in Cardiocenter of the University Hospital Královské Vinohrady in Prague using relatively new technique - transcatheter aortic valve implantation. In the first part of the thesis are given information from anatomy and physiology of the cardiovascular system, focusing on the heart and heart valves. In the section on pathophysiology are described cardiac valve diseases, with emphasis on aortic valve stenosis. Diagnosis and therapeutic procedures of the disease are described. The following are basic information about the patient and his health. Nursing part of the thesis describes the nursing process in accordance with the model Theory of basic nursing care by Virginia Henderson. According to this model nursing process for selected 84-year-old patient was compiled. This includes short and long term plan of care. Short-term plan of care is designed for the second day of hospitalisation, which is the day of the operation. Long-term care plan is set for a period of approximately 7 days. In the thesis is also mentioned patient 's social and psychology domain. The thesis deals with the education of selected patient, too.
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Ischemic heart disease-from pathophysiology of ischemic mitral regurgitation to percutaneous coronary intervention
Kočka, Viktor ; Widimský, Petr (advisor) ; Mates, Martin (referee) ; Želízko, Michael (referee)
Ischemic heart disease - from pathophysiology of ischemic mitral regurgitation to percutaneous coronary intervention As. MUDr. Viktor Kočka Summary Ischemic mitral regurgitation (IMR) and myocardial revascularization are from pathophysiological perspective closely linked. We first defined the incidence of IMR in current cardiology to be 129 patients per 1 million population annually. These patients have high mortality of 54% during 5 year follow-up. There is pathophysiological hypothesis of association between myocardial viability and IMR and we have proven this thesis to be correct. The presence of at least 5 viable segments of myocardium is a significant predictor of IMR improvement after revascularization. It is noteworthy that dimension of left ventricle indexed to body surface area is a better predictor of long term prognosis than the hemodynamic significance of IMR. We have also found surprisingly robust association between previous revascularization and better prognosis, even after in average 10 years. Further we have focused on the topic of percutaneous coronary intervention (PCI). Pathophysiology of neointimal hyperplasia (NIH) as a basis of clinical in-stent restenosis was examined on animal model. First, novel nanocrystalline diamond (NCD) coronary stent coating was developed with the help of...
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Ischemic heart disease-from pathophysiology of ischemic mitral regurgitation to percutaneous coronary intervention
Kočka, Viktor ; Widimský, Petr (advisor) ; Mates, Martin (referee) ; Želízko, Michael (referee)
Ischemic heart disease - from pathophysiology of ischemic mitral regurgitation to percutaneous coronary intervention As. MUDr. Viktor Kočka Summary Ischemic mitral regurgitation (IMR) and myocardial revascularization are from pathophysiological perspective closely linked. We first defined the incidence of IMR in current cardiology to be 129 patients per 1 million population annually. These patients have high mortality of 54% during 5 year follow-up. There is pathophysiological hypothesis of association between myocardial viability and IMR and we have proven this thesis to be correct. The presence of at least 5 viable segments of myocardium is a significant predictor of IMR improvement after revascularization. It is noteworthy that dimension of left ventricle indexed to body surface area is a better predictor of long term prognosis than the hemodynamic significance of IMR. We have also found surprisingly robust association between previous revascularization and better prognosis, even after in average 10 years. Further we have focused on the topic of percutaneous coronary intervention (PCI). Pathophysiology of neointimal hyperplasia (NIH) as a basis of clinical in-stent restenosis was examined on animal model. First, novel nanocrystalline diamond (NCD) coronary stent coating was developed with the help of...
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Nursing Care of the Patient after Transcatheter Aortic Valve Implantation
Jamrich, Lukáš ; Vaňková, Milena (advisor) ; Kočka, Viktor (referee)
Resume This bachelor thesis is a case study of nursing care of 84-year-old patient hospitalised for aortic stenosis. The patient was treated in Cardiocenter of the University Hospital Královské Vinohrady in Prague using relatively new technique - transcatheter aortic valve implantation. In the first part of the thesis are given information from anatomy and physiology of the cardiovascular system, focusing on the heart and heart valves. In the section on pathophysiology are described cardiac valve diseases, with emphasis on aortic valve stenosis. Diagnosis and therapeutic procedures of the disease are described. The following are basic information about the patient and his health. Nursing part of the thesis describes the nursing process in accordance with the model Theory of basic nursing care by Virginia Henderson. According to this model nursing process for selected 84-year-old patient was compiled. This includes short and long term plan of care. Short-term plan of care is designed for the second day of hospitalisation, which is the day of the operation. Long-term care plan is set for a period of approximately 7 days. In the thesis is also mentioned patient 's social and psychology domain. The thesis deals with the education of selected patient, too.
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