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	Study of the unique signaling pathway of Ser/Thr protein kinase StkP and phosphatase PhpP in Streptococcus pneumoniae Keil, Jan ; Ulrych, Aleš (advisor) ; Bobková, Šárka (referee) The major human pathogen Streptococcus pneumoniae is a unique model for the study of eukaryotic-type serine/threonine protein kinases and its cognate phosphatases in bacteria, since it encodes only a single signaling pair composed of the StkP protein kinase and PhpP phosphatase. This signaling pair plays a role in several cellular processes, mainly in cell wall biosynthesis and cell division. StkP and PhpP proteins with a pleiotropic effect appear to regulate a complex signaling cascade by phosphorylation of many substrates. However, only a few have been characterized so far. Using MS analysis, we have identified about 90 phosphopeptides that are potential substrates for the StkP kinase and PhpP phosphatase. This diploma thesis is focused on the characterization of the new substrate Spr0929 and its role in pneumococcal physiology. One of the objectives was to investigate cell morphology of strains carrying deletion of the spr0929 gene in different genetic backgrounds. It turned out that the role of Spr0929 in cell morphology is strain specific. The growth curves of strains with this deletion were compared to that of the wild type in various physiological conditions as well. As Spr0929 contains a nucleoid-associated domain called NdpA, determination of its cell localization was an important... Detailed record
	Secondary structure assignment Keil, Jan ; Novotný, Marian (advisor) ; Treťjačenko, Vjačeslav (referee) Detailed record
	Strategická analýza podniku Vodafone Czech Republic a. s. Keil, Jan ; Středová, Ivana (advisor) ; Theodor, Michal (referee) Záměrem mojí diplomové práce bylo provést strategickou analýzu společnosti Vodafone Czech Rebublic a. s. Nejdříve byla provedena analýza externí (tedy mikrookolí a makrookolí) a pak na ní navazuje interní analýzy. Výsledky těchto dvou analýz jsou využity v ve SWOT analýze, na zaákladě které je provedeno doporučení pro další strategie. V práci jsou také analyzovány strategie, které podnik využívá už nyní. Detailed record

See also: similar author names
1	Keil, Jindřich

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