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Osteoporosis management at general practitioners level
Karaščák, Roman ; Vytřísalová, Magda (advisor) ; Kostřiba, Jan (referee)
CHARLES UNIVERSITY IN PRAGUE Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate: Mgr. Roman Karaščák Title of thesis: Osteoporosis management at general practitioners level Director of studies: PharmDr. Magda Vytřísalová, Ph.D. Consultant of studies: PharmDr. Leoš Fuksa, Ph.D. Osteoporosis, the most prevalent human skeletal metabolism-based disease, is manifested by the weakened bone micro-structure and its lowered endurance against mechanical impacts which results to the higher fracture incidence. Nowadays it is considered to be a lifestyle disease. Contnuous rise of osteoporosis incidence and prevalence may become even more rapid in the future and could overwhelm the public healthcare system. Post-menopausal women and elderly people are threatened by an involutional osteoporosis. In Czech Republic, the principal provider is general practitioner, who ensures comprehensive healthcare for his patients. In order to do so, because of the present limitations, he has an obligation to cooperate with and to adress his patients to certain specialists - osteologists, endocrinologists, internists, orthopedists and gynecologists. We conducted a cross-sectional questionnairy study. Questionnaires were sent to 1 500 random-selected general practitioners in the two-round...
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Osteoporosis management at general practitioners level
Karaščák, Roman ; Vytřísalová, Magda (advisor) ; Kostřiba, Jan (referee)
CHARLES UNIVERSITY IN PRAGUE Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate: Mgr. Roman Karaščák Title of thesis: Osteoporosis management at general practitioners level Director of studies: PharmDr. Magda Vytřísalová, Ph.D. Consultant of studies: PharmDr. Leoš Fuksa, Ph.D. Osteoporosis, the most prevalent human skeletal metabolism-based disease, is manifested by the weakened bone micro-structure and its lowered endurance against mechanical impacts which results to the higher fracture incidence. Nowadays it is considered to be a lifestyle disease. Contnuous rise of osteoporosis incidence and prevalence may become even more rapid in the future and could overwhelm the public healthcare system. Post-menopausal women and elderly people are threatened by an involutional osteoporosis. In Czech Republic, the principal provider is general practitioner, who ensures comprehensive healthcare for his patients. In order to do so, because of the present limitations, he has an obligation to cooperate with and to adress his patients to certain specialists - osteologists, endocrinologists, internists, orthopedists and gynecologists. We conducted a cross-sectional questionnairy study. Questionnaires were sent to 1 500 random-selected general practitioners in the two-round...
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Dysmetabolic mechanism for defining metabolit syndrome.
Karaščák, Roman ; Semecký, Vladimír (advisor) ; Martiník, Karel (referee)
5 Abstract of diploma thesis Author: Roman Karaščák Title: Dysmetabolic mechanism in the definition of metabolic syndrome Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Field of Study: Pharmacy The aim of this thesis is to assess the significance of insulin resistance in the pathophysiology of metabolic syndrome by measuring levels of the body fat burning during fasting and during the oral glucose tolerance test (OGTT). Next, we tried to establish a typology of different insulin groups. Under this classification, we expect identification of stage of pathology of the metabolism by insulin response to glucose load and the consequent effect on tissue metabolism. The experiment included 273 subjects who underwent OGTT and evaluation of the current fat burning device DeltatracTM . The withdrawn blood samples were determined in order to provide levels of insulin and c-peptide by methods imunoradiometric determination/analysis (IRMA). The determined values were statistically processed in order to assess particular relationships. Results section describes the obtained relations. We found BMI dependence on fasting and glucose induced inzulinemy. Dependence of the energy use of fats on inzulinemy was not proven. Next, we made a proposal insulin typology. In conclusion, the study of...
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