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Electeophysiological response of the central nervous system to prolonged visual stimulation in migraine
Bednář, Michal ; Kubová, Zuzana (advisor) ; Kraus, Josef (referee) ; Kadaňka, Zdeněk (referee)
Electrophysiological response of the central nervous system to prolonged visual stimulation in migraine Migraine is a paroxysmal disorder with complex symptoms (prodromal stage (aura), headache phase, post-paroxysmal phase) by nature it is primarily a dysfunction of the central nervous system with the absence of structural changes discernible on routine neuroradiological imaging. A part of the so far elusive pathophysiology of migraine, is the abnormal central processing of sensory information that has both clinical (in visual perception i.e. photophobia) as well as electrophysiological correlates. In the last three decades, the development of fundamental research in the neurophysiology of central neurogenic dysfunction in migraines (where visual evoked potentials VEP play a pivotal role), has been accompanied by numerous debates on the contradictory findings suggestive of cortical hyperexcitability or hypoexcitability. In order to unify the concept, it would be appropriate to refer to migraineurs as having cortical hyper-responsibility, which implies an increased sensitivity to facilitatory or inhibitory stimuli. The discrepancies in electrophysiology findings gradually grew in number and a significance towards a migraine specific electrophysiological abnormality emerged - a deficit in decrement amplitude...
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Electeophysiological response of the central nervous system to prolonged visual stimulation in migraine
Bednář, Michal ; Kubová, Zuzana (advisor) ; Kraus, Josef (referee) ; Kadaňka, Zdeněk (referee)
Electrophysiological response of the central nervous system to prolonged visual stimulation in migraine Migraine is a paroxysmal disorder with complex symptoms (prodromal stage (aura), headache phase, post-paroxysmal phase) by nature it is primarily a dysfunction of the central nervous system with the absence of structural changes discernible on routine neuroradiological imaging. A part of the so far elusive pathophysiology of migraine, is the abnormal central processing of sensory information that has both clinical (in visual perception i.e. photophobia) as well as electrophysiological correlates. In the last three decades, the development of fundamental research in the neurophysiology of central neurogenic dysfunction in migraines (where visual evoked potentials VEP play a pivotal role), has been accompanied by numerous debates on the contradictory findings suggestive of cortical hyperexcitability or hypoexcitability. In order to unify the concept, it would be appropriate to refer to migraineurs as having cortical hyper-responsibility, which implies an increased sensitivity to facilitatory or inhibitory stimuli. The discrepancies in electrophysiology findings gradually grew in number and a significance towards a migraine specific electrophysiological abnormality emerged - a deficit in decrement amplitude...
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