|
|
Dissolution testing of tablets containing theophylline and mixtures of two types of calcium hydrogen phosphates and lactose
Dušková, Lucie ; Šklubalová, Zdeňka (advisor) ; Jirásková, Johana (referee)
1 Abstract Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Lucie Dušková Title of Thesis: Dissolution testing of tablets containing theophylline and mix- tures of two types of calcium hydrogen phosphates and lactose The aim of this diploma thesis was to study effect of the composition of pow- ders on the tablets dissolution. The mixtures that had been used to prepare the tablets that were composed of three types of fillers - lactose, calcium hyd- rogen phosphate anhydrous and dihydrate, theophylline as model drug and magnesium stearate as lubricant. Dissolution tests were performed using those prepared tablets. Basket dissolution method was used (USP-1) with 0.1M hyd- rochloric acid as dissolution medium. The results of this work show that different fillers have different effect on the dissolution tests. Total amount and release speed of theophylline from tablets can be influenced by the ratio of lactose and one of two used types of calcium hydrogen phosphate. The fastest drug release was observed in tablets containing high percentage of lactose. The release speed and also the amount of released drug is decreasing with the increasing amount of both types of calcium hydrogen phosphate...
|
|
|
The influence of the tableting speed on the compaction process
Marcinek, Tomáš ; Ondrejček, Pavel (advisor) ; Jirásková, Johana (referee)
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of Pharmaceutical Technology Consultant: Mgr. Pavel Ondrejček, Ph.D. Student: Tomáš Marcinek Title of Thesis: The influence of the tableting speed on the compaction process The main aim of this thesis was to determine the influence of tableting speed on the compaction process of four substances. The compaction process was evaluated by three- exponential equation. The parameters of this equation describe the individual phases of compression, the precompression phase, the phase of elastic deformation and the phase of plastic deformation. Furthermore, the effect of tableting speed on the compressibility of the material was studied using the force-displacement record. Finally, the influence of tableting speed on tensile strength of the prepared tablets was evaluated. Four materials were used for the evaluation. Microcrystalline cellulose Avicel PH-102 and dicalcium phosphate dihydrate DI-CAFOS were used as model fillers. Theophylline and paracetamol were used as model drugs. The course of the compaction process was evaluated at five compaction speeds. The results of this evaluation revealed different behavior of used materials. Furthermore different influence on the compaction process by changing compaction speed was...
|
|
|
A comparison of viscoelastic properties of mixtures of lactose and different lubricants using the stress relaxation test.
Přeučilová, Michaela ; Svačinová, Petra (advisor) ; Jirásková, Johana (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Consultant: Mgr. Petra Svačinová, Ph.D. Student: Michaela Přeučilová Title of Thesis: A comparison of viscoelastic properties of mixtures of lactose and different lubricants using the stress relaxation test This diploma thesis deals with viscoelastic properties of pharmaceutical excipients and tensile strength of tablets made of these excipients. Theoretical part is dedicated to description of lactose and lubricants, further the tablets compressibility and compression energy profile are described. The end of theoretical part deals with the stress relaxation test, with evaluation methods and the stress relaxation test influence on lactose tablets with different types of lubricants as well. The experimental part deals with the evaluation of the viscoelastic properties of two types of lactose and their mixtures with different types of lubricants at concentration of 1%. These characteristics were evaluated by stress relaxation test. All tablets were compressed by compression forces of 13 kN and 15 kN with dwell time 180 seconds. The study was about differences between two types of lactose, effect of lubricants and effect of two different compression forces on parameters of elasticity A1 -A3 and...
|
|
|
A comparison of viscoelastic properties of mixtures of lactose and different lubricants using the stress relaxation test.
Přeučilová, Michaela ; Svačinová, Petra (advisor) ; Jirásková, Johana (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Consultant: Mgr. Petra Svačinová, Ph.D. Student: Michaela Přeučilová Title of Thesis: A comparison of viscoelastic properties of mixtures of lactose and different lubricants using the stress relaxation test This diploma thesis deals with viscoelastic properties of pharmaceutical excipients and tensile strength of tablets made of these excipients. Theoretical part is dedicated to description of lactose and lubricants, further the tablets compressibility and compression energy profile are described. The end of theoretical part deals with the stress relaxation test, with evaluation methods and the stress relaxation test influence on lactose tablets with different types of lubricants as well. The experimental part deals with the evaluation of the viscoelastic properties of two types of lactose and their mixtures with different types of lubricants at concentration of 1%. These characteristics were evaluated by stress relaxation test. All tablets were compressed by compression forces of 13 kN and 15 kN with dwell time 180 seconds. The study was about differences between two types of lactose, effect of lubricants and effect of two different compression forces on parameters of elasticity A1 -A3 and...
|
|
|
The influence of the tableting speed on the compaction process
Marcinek, Tomáš ; Ondrejček, Pavel (advisor) ; Jirásková, Johana (referee)
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of Pharmaceutical Technology Consultant: Mgr. Pavel Ondrejček, Ph.D. Student: Tomáš Marcinek Title of Thesis: The influence of the tableting speed on the compaction process The main aim of this thesis was to determine the influence of tableting speed on the compaction process of four substances. The compaction process was evaluated by three- exponential equation. The parameters of this equation describe the individual phases of compression, the precompression phase, the phase of elastic deformation and the phase of plastic deformation. Furthermore, the effect of tableting speed on the compressibility of the material was studied using the force-displacement record. Finally, the influence of tableting speed on tensile strength of the prepared tablets was evaluated. Four materials were used for the evaluation. Microcrystalline cellulose Avicel PH-102 and dicalcium phosphate dihydrate DI-CAFOS were used as model fillers. Theophylline and paracetamol were used as model drugs. The course of the compaction process was evaluated at five compaction speeds. The results of this evaluation revealed different behavior of used materials. Furthermore different influence on the compaction process by changing compaction speed was...
|
|
|
Dissolution testing of tablets containing theophylline and mixtures of two types of calcium hydrogen phosphates and lactose
Dušková, Lucie ; Šklubalová, Zdeňka (advisor) ; Jirásková, Johana (referee)
1 Abstract Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Lucie Dušková Title of Thesis: Dissolution testing of tablets containing theophylline and mix- tures of two types of calcium hydrogen phosphates and lactose The aim of this diploma thesis was to study effect of the composition of pow- ders on the tablets dissolution. The mixtures that had been used to prepare the tablets that were composed of three types of fillers - lactose, calcium hyd- rogen phosphate anhydrous and dihydrate, theophylline as model drug and magnesium stearate as lubricant. Dissolution tests were performed using those prepared tablets. Basket dissolution method was used (USP-1) with 0.1M hyd- rochloric acid as dissolution medium. The results of this work show that different fillers have different effect on the dissolution tests. Total amount and release speed of theophylline from tablets can be influenced by the ratio of lactose and one of two used types of calcium hydrogen phosphate. The fastest drug release was observed in tablets containing high percentage of lactose. The release speed and also the amount of released drug is decreasing with the increasing amount of both types of calcium hydrogen phosphate...
|
guest ::
RSS feed.