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Effect of Drug Switching on Lower Urinary Tract Dynamics and Quality of Life in Patients with Overactive Bladder
Holub, Lukáš ; Broďák, Miloš (advisor) ; Záleský, Miroslav (referee) ; Vidlář, Aleš (referee)
The aim of this dissertation is to evaluate the effect of solifenacin on quality of life (QoL) of patients previously treated with another antimuscarinic for overactive bladder (OAB) and to compare the effects of solifenacin according to previous antimuscarinic treatment. The study evaluated a representative sample of the OAB population (2,000 patients enrolled in 60 centres in the Czech Republic, 1,481 patients completed all five trials and 1,892 patients had a baseline and at least one post-treatment assessment). Methods for validation were treatment satisfaction questionnaires: the Perceived Satisfaction with Treatment Questionnaire (TS VAS), the short form of the Overactive Bladder Questionnaire (OAB q SF) and the European Quality of Life Questionnaire (EuroQoL - EQ-5D-5L). Improvements in QoL and OAB symptoms were observed over 12 months in a population of patients treated with solifenacin 5-10 mg and previously treated with other antimuscarinics. The development of OAB total score was not significantly (p = 0.45) affected by previous treatment. OAB q SF scores, including the total HRQoL score, all HRQoL subgroups and symptom severity scores, improved over the follow-up period. Changes in TS VAS scores also showed improvement in overall QoL during the study period. EQ-5D-5L showed a shift...
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Convergence of Copyright and Trademark Protection
Holub, Lukáš ; Žikovská, Petra (advisor) ; Holcová, Irena (referee)
Convergence of Copyright and Trademark Protection Key Words: Copyright, Trademark, Protection, Convergence Abstract: The thesis analyzes the concept of copyright and trademark protection in Czech law and the consequences of their simultaneous operation. The aim is to determine whether the existing legislation responds the current trends and demands in our society, where business and arts are becoming interconnected and where the boundaries between those disciplines are blurred. Both protections are initially assigned to theoretical context of legal branches of intellectual property and intangible property. The author also deals with current conception of ownership in Civil Code. Following chapters are based on the principles of civil (continental) law concepts of copyright law and industrial property law established in this part. Subsequently the regulation of copyright protection and trademark protection is discussed in two separate chapters. Those chapters are divided into identical sub-chapters to highlight similarities and differences of both legal institutes. The focus is on subjects of both protections, their beneficiaries, formation, content, duration, means, limitations, international context and the issues of licensing. In the chapter devoted to convergence, various situations which might occur...
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Annotated Translation. Rosenberg, Tina: How one of the most obese countries on earth took on the soda giants. Guardian, 3 November 2015.
Holub, Lukáš ; Mraček, David (advisor) ; Jettmarová, Zuzana (referee)
The objective of this thesis is to translate an online article called How one of the most obese countries on earth took on the soda giants, published in The Guardian, from Czech to English. The article, written by the US journalist Tina Rosenberg in November 2015, informs about the role soda plays in Mexico and attempts to trace the political and cultural circumstances that led to the current situation in the country. The second part of this thesis contains a commentary comprising the analysis of the text, description of the method of translation and the analysis and typology of translation problems, translation procedures and translation shifts that occurred during the process. KEY WORDS obesity, consumption of sugary drinks, translation, translation analysis, translation techniques
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The deshumanization in Federico García Lorca's hand puppet theatre
Holub, Lukáš ; Sánchez Fernández, Juan Antonio (advisor) ; Kožnerová, Tereza (referee)
This thesis analyses theatre work of Federico García Lorca with the particular focus put on his puppet theatre which was created by Lorca from 1919 to his death in 1936. The aim of the thesis is to analyse distinctive features and pecularities of this theatrical form contrasted with traditional theatrical performances, with The Puppet Play of Don Cristóbal being the core work. The thesis also focuses on the tradition of puppet theatre and tries to trace the influence of Lorca's contemporaries on his work, such as Ramón del Valle-Inclán or José Ortega y Gasset. Another focus will be put on his concept of the hand-puppet itself, and that is in the light of the process of the so called dehumanization, in other words - the dehumanization of the drama presented by the puppets. Keywords Lorca, hand-puppet, theater, dehumanization.
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Convergence of Copyright and Trademark Protection
Holub, Lukáš ; Žikovská, Petra (advisor) ; Holcová, Irena (referee)
Convergence of Copyright and Trademark Protection Key Words: Copyright, Trademark, Protection, Convergence Abstract: The thesis analyzes the concept of copyright and trademark protection in Czech law and the consequences of their simultaneous operation. The aim is to determine whether the existing legislation responds the current trends and demands in our society, where business and arts are becoming interconnected and where the boundaries between those disciplines are blurred. Both protections are initially assigned to theoretical context of legal branches of intellectual property and intangible property. The author also deals with current conception of ownership in Civil Code. Following chapters are based on the principles of civil (continental) law concepts of copyright law and industrial property law established in this part. Subsequently the regulation of copyright protection and trademark protection is discussed in two separate chapters. Those chapters are divided into identical sub-chapters to highlight similarities and differences of both legal institutes. The focus is on subjects of both protections, their beneficiaries, formation, content, duration, means, limitations, international context and the issues of licensing. In the chapter devoted to convergence, various situations which might occur...
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