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Role and significance of Joseph in the Gospel of Matthew
Hladík, Michal ; Brož, Jaroslav (advisor) ; Scarano, Angelo (referee)
This diploma thesis Role and Significance of Joseph in the Gospel of Matthew is divided into five chapters. The first two chapters are an essential basis for a study of the next three chapters that are the core of this thesis. Thanks to these, it can be said who Joseph is. The first chapter deals with the linguistic and literary analysis of the first two chapters of the Gospel of Matthew, since these two chapters are seen as a source of exploration into Joseph's character. The second chapter of this thesis is concerned with a synoptic comparison of the gospel texts which speak about Joseph. The third chapter follows up on Joseph's position, task and role in Jesus's genealogy, as recorded by Matthew. The fourth chapter follows up Joseph's role as Mary's husband. The biblical narration is put into the context of entering into a Jewish marriage with all the sequences of events and requirements. Further, the fourth chapter elaborates on Joseph's role as Jesus's father before the Law, including all the rights and obligations Joseph had to fulfil towards Jesus. The fifth chapter enquires into Matthew's second chapter from Joseph's point of view. Here Joseph is situated into his historical, political and social contexts. This chapter also deals with the trust between God and Joseph because Joseph's entire...
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Analytical evaluation of the pharmaceutical formulations using chromatographic methods I
Hladík, Michal ; Mokrý, Milan (advisor) ; Kastner, Petr (referee)
Analytical evaluation of the drugs using chromatographic methods I. (Determination of the conditions for simultaneous evaluation of clotrimazole and benzylalcohol) Thesis Michal Hladík Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Analysis Optimum chromatographic conditions for simultaneous HPLC determination of clotrimazole and benzylacohol in a pharmaceutical formulations (2 % cream) were elaborated. The best results was achieved using chromatographic column Separon SGX CN, 7 μm, 150 x 4 mm I. D. (Tessek Prague, Czech Republic). The mobile phase consisted of mixture of acetonitrile and aqueous solution of K2HPO4 0.05 mol/l (60 : 40), pH 6.7 (adjusted with 10 % H3PO4). The flow rate was 0.8 ml/min. The UV detector set at 268 nm was used. Method was validated for linearity and robustness. Complete validation will be an aim of the next rigorous work.
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Polymorphism of drug metabolizing enzymes as a potential target of prevention of serious treatment complications in neonates and infants
Hronová, Karolína ; Slanař, Ondřej (advisor) ; Paluch, Zoltán (referee) ; Hladík, Michal (referee)
Univerzita Karlova 1. lékařská fakulta Studijní program: Biomedicína Studijní obor: Preventivní medicína MUDr. Karolína Hronová Polymorfismus genů účastnících se v metabolismu léčiv jako potenciální cíl prevence závažných komplikací léčby u novorozenců a dětí Polymorphism of drug metabolizing enzymes as a potential target of prevention of serious treatment complications in neonates and infants Disertační práce- ABSTRAKT V ANGLICKÉM JAZYCE Školitel: prof. MUDr. Ondřej Slanař, Ph.D. Konzultant: MUDr. Pavla Pokorná, PhD. Praha, 2018 Abstract Background and aims: The safety of analgosedative drugs includes drug interactions, adverse effects, withdrawal syndrome and drug dependence are factors that significantly affect morbidity and mortality. Its prevention is critical for quality improvement of care in paediatric patients. The aim of the thesis was to evaluate the prediction of efficacy and safety of analgosedative drugs sufentanil, midazolam, tramadol and valproic acid in neonates and children based on the occurrence of selected pharmacogenetic biomarkers. The incidence of drug interactions of phenobarbital with other analgosedative drugs has also been evaluated. Methodology: The thesis is based on two studies conducted on Intensive and Resuscitation Care Unit of the Clinic of Paediatric and Adolescent...
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Polymorphism of drug metabolizing enzymes as a potential target of prevention of serious treatment complications in neonates and infants
Hronová, Karolína ; Slanař, Ondřej (advisor) ; Paluch, Zoltán (referee) ; Hladík, Michal (referee)
Univerzita Karlova 1. lékařská fakulta Studijní program: Biomedicína Studijní obor: Preventivní medicína MUDr. Karolína Hronová Polymorfismus genů účastnících se v metabolismu léčiv jako potenciální cíl prevence závažných komplikací léčby u novorozenců a dětí Polymorphism of drug metabolizing enzymes as a potential target of prevention of serious treatment complications in neonates and infants Disertační práce- ABSTRAKT V ANGLICKÉM JAZYCE Školitel: prof. MUDr. Ondřej Slanař, Ph.D. Konzultant: MUDr. Pavla Pokorná, PhD. Praha, 2018 Abstract Background and aims: The safety of analgosedative drugs includes drug interactions, adverse effects, withdrawal syndrome and drug dependence are factors that significantly affect morbidity and mortality. Its prevention is critical for quality improvement of care in paediatric patients. The aim of the thesis was to evaluate the prediction of efficacy and safety of analgosedative drugs sufentanil, midazolam, tramadol and valproic acid in neonates and children based on the occurrence of selected pharmacogenetic biomarkers. The incidence of drug interactions of phenobarbital with other analgosedative drugs has also been evaluated. Methodology: The thesis is based on two studies conducted on Intensive and Resuscitation Care Unit of the Clinic of Paediatric and Adolescent...
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Analytical evaluation of the pharmaceutical formulations using chromatographic methods I
Hladík, Michal ; Mokrý, Milan (advisor) ; Kastner, Petr (referee)
Analytical evaluation of the drugs using chromatographic methods I. (Determination of the conditions for simultaneous evaluation of clotrimazole and benzylalcohol) Thesis Michal Hladík Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Analysis Optimum chromatographic conditions for simultaneous HPLC determination of clotrimazole and benzylacohol in a pharmaceutical formulations (2 % cream) were elaborated. The best results was achieved using chromatographic column Separon SGX CN, 7 μm, 150 x 4 mm I. D. (Tessek Prague, Czech Republic). The mobile phase consisted of mixture of acetonitrile and aqueous solution of K2HPO4 0.05 mol/l (60 : 40), pH 6.7 (adjusted with 10 % H3PO4). The flow rate was 0.8 ml/min. The UV detector set at 268 nm was used. Method was validated for linearity and robustness. Complete validation will be an aim of the next rigorous work.
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