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National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
Antimicrobial susceptibility testing of newly synthesized compounds
 Benková, Markéta ; Marek, Jan (advisor) ; Žemličková, Helena (referee) ; Hanovcová, Irena (referee)
In the dissertation thesis we dealt with the antimicrobial susceptibility testing (against gram-positive and gram-negative bacteria, yeasts and filamentous fungi) of newly synthesized compounds and their structure-antimicrobial activity relationship monitoring. These compounds based on quaternary ammonium salts with various structural modifications were prepared in cooperation with the Department of Toxicology and Military Pharmacy of the Faculty of Military Health Sciences of the University of Defence and Biomedical Research Centre at the University Hospital Hradec Králové on a joint project of the Czech Health Research Council. Selection of a methodology for antimicrobial susceptibility testing was the first part of the thesis. The microdilution broth method, which was successfully implemented at the department, was chosen for this purpose. The in vitro testing of selected synthesized compounds against several bacterial and fungal strains was the next phase of the work. Several substances have also been evaluated for the green microalgae growth inhibition (in terms of environmental friendliness). In addition, cytotoxic effects were tested on mammalian cell line to assess whether the compounds were more suitable as antiseptics or surface disinfectants. Several substances active against individual...
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Antimicrobial susceptibility testing of newly synthesized compounds
 Benková, Markéta ; Marek, Jan (advisor) ; Žemličková, Helena (referee) ; Hanovcová, Irena (referee)
In the dissertation thesis we dealt with the antimicrobial susceptibility testing (against gram-positive and gram-negative bacteria, yeasts and filamentous fungi) of newly synthesized compounds and their structure-antimicrobial activity relationship monitoring. These compounds based on quaternary ammonium salts with various structural modifications were prepared in cooperation with the Department of Toxicology and Military Pharmacy of the Faculty of Military Health Sciences of the University of Defence and Biomedical Research Centre at the University Hospital Hradec Králové on a joint project of the Czech Health Research Council. Selection of a methodology for antimicrobial susceptibility testing was the first part of the thesis. The microdilution broth method, which was successfully implemented at the department, was chosen for this purpose. The in vitro testing of selected synthesized compounds against several bacterial and fungal strains was the next phase of the work. Several substances have also been evaluated for the green microalgae growth inhibition (in terms of environmental friendliness). In addition, cytotoxic effects were tested on mammalian cell line to assess whether the compounds were more suitable as antiseptics or surface disinfectants. Several substances active against individual...
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Aplikace bioaktivní sklo-keramiky v ortopedii
Urban, Karel ; Hanovcová, Irena ; Fakultní nemocnice.
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