|
|
Perioperative prognostic factors in breast cancer
Černá, Monika ; Třeška, Vladislav (advisor) ; Gaťek, Jiří (referee) ; Šiller, Jiří (referee) ; Jandík, Pavel (referee)
Introduction: Breast cancer still remains the most common malignancy in women and its incidence is slowly increasing. A marked reduction of mortality has been achieved in the last 10 years thanks to modern diagnostic methods, mammary screening, and comprehensive and targeted cancer therapy. Modern diagnostic capabilities not only allow early diagnosis of a primary tumor lesion and precise determination of its biological nature before commencing treatment, but they also enable early diagnosis of local and regional recidives, including diagnosis of metastases in distant organs. In addition to clinical examination, conventional and complementary imaging examinations and tumor markers our objective was to determine the importance and use of growth factors in relation to the overall prognosis. The growth factors physiologically act already during the ontogenetic period when they control cell growth, proliferation, differentiation and apoptotic processes. It is known that they take part in the tumor growth processes which are characterized by autonomous behavior, increased proliferative activity, distinct differentiation activity and reduced apoptosis. Growth factors work as autoregulation factors in the neoplastic process as well as through their paracrine effects mediated by more or less specific receptors....
|
|
|
New Possibilities of Prevention and Monitoring of Breast Cancer
Hosnedlová, Andrea ; Třeška, Vladislav (advisor) ; Jandík, Pavel (referee) ; Gaťek, Jiří (referee)
Introduction: Breast cancer is one of the most common cancer in women, whose incidence rate is significantly increasing worldwide. Mortality has been reduced over the past few years, thanks to constantly improving diagnostic methods, full-scale mammography screening as well as comprehensive treatment. The success rate of treatment is known to depend on the earliness of diagnosis of breast cancer. Therefore, the scientists endeavour to find and optimize laboratory diagnosis of tumors using serum or tissue tumor markers. However, thus far, there is no biomarker suitable for screening or diagnosis of the early stage of breast cancer. Aim of the study: Our main goal was to study classic tumor markers and many other molecules associated with the process of carcinogenesis, namely markers of angiogenesis and lymphangiogenesis, growth factors, multifunctional proteins and proteases to assess their benefit of evaluation of tumor aggressiveness, extent of surgery, choice of the subsequent therapy and recurrence detection. A partial objective was to compare preoperative levels of these biomarkers (CEA, CA 15-3, CYFRA 21-1, TPA, TK, MonoTotal, VEGF, EGF, IGF-1, IGF-BP3, Osteopontin, Osteoprotegerin, Matrix Metalloproteinases MMP-2 and MMP-9) between a group of patients with malignant and benign breast disease....
|
|
|
Biological activity of breast cancer
Zedníková, Ilona ; Třeška, Vladislav (advisor) ; Gaťek, Jiří (referee) ; Jandík, Pavel (referee)
Structured abstract Introduction: Breast cancer is the most common malignant disease in women and represents a worldwide problem. By using up-to-date diagnostics methods, mammography screening as well as complex treatment, mortality was substantially reduced. However, the incidence of disease is constantly growing in a moderate way. The struggle against this disease has several levels, such as prevention, primary tumor therapy as well as solution of recurrent disease or generalization of this. Therefore, it is very significant to evaluate prognosis on the basis of biological characteristics of tumor and to determine the right individual therapy in each patient. Aim of the study: Our aim was to determine a group of patients with malignant breast disease on the basis of biological characteristics of the tumor axillary exenteration might be omitted in if there is the presence of sentinel lymph node metastasis, which can reduce morbidity connected with this surgery without worsening prognosis. Group and methodology: The research project lasted from June 2012 to June 2015. It was an introspective randomized study where the main investigated group was made up of women with primarily surgically treated mammary cancer who underwent sentinel lymph node biopsy (SNB) within surgery. These were divided into three...
|
|
|
New Possibilities of Prevention and Monitoring of Breast Cancer
Hosnedlová, Andrea ; Třeška, Vladislav (advisor) ; Jandík, Pavel (referee) ; Gaťek, Jiří (referee)
Introduction: Breast cancer is one of the most common cancer in women, whose incidence rate is significantly increasing worldwide. Mortality has been reduced over the past few years, thanks to constantly improving diagnostic methods, full-scale mammography screening as well as comprehensive treatment. The success rate of treatment is known to depend on the earliness of diagnosis of breast cancer. Therefore, the scientists endeavour to find and optimize laboratory diagnosis of tumors using serum or tissue tumor markers. However, thus far, there is no biomarker suitable for screening or diagnosis of the early stage of breast cancer. Aim of the study: Our main goal was to study classic tumor markers and many other molecules associated with the process of carcinogenesis, namely markers of angiogenesis and lymphangiogenesis, growth factors, multifunctional proteins and proteases to assess their benefit of evaluation of tumor aggressiveness, extent of surgery, choice of the subsequent therapy and recurrence detection. A partial objective was to compare preoperative levels of these biomarkers (CEA, CA 15-3, CYFRA 21-1, TPA, TK, MonoTotal, VEGF, EGF, IGF-1, IGF-BP3, Osteopontin, Osteoprotegerin, Matrix Metalloproteinases MMP-2 and MMP-9) between a group of patients with malignant and benign breast disease....
|
|
|
Biological activity of breast cancer
Zedníková, Ilona ; Třeška, Vladislav (advisor) ; Gaťek, Jiří (referee) ; Jandík, Pavel (referee)
Structured abstract Introduction: Breast cancer is the most common malignant disease in women and represents a worldwide problem. By using up-to-date diagnostics methods, mammography screening as well as complex treatment, mortality was substantially reduced. However, the incidence of disease is constantly growing in a moderate way. The struggle against this disease has several levels, such as prevention, primary tumor therapy as well as solution of recurrent disease or generalization of this. Therefore, it is very significant to evaluate prognosis on the basis of biological characteristics of tumor and to determine the right individual therapy in each patient. Aim of the study: Our aim was to determine a group of patients with malignant breast disease on the basis of biological characteristics of the tumor axillary exenteration might be omitted in if there is the presence of sentinel lymph node metastasis, which can reduce morbidity connected with this surgery without worsening prognosis. Group and methodology: The research project lasted from June 2012 to June 2015. It was an introspective randomized study where the main investigated group was made up of women with primarily surgically treated mammary cancer who underwent sentinel lymph node biopsy (SNB) within surgery. These were divided into three...
|
|
|
Perioperative prognostic factors in breast cancer
Černá, Monika ; Třeška, Vladislav (advisor) ; Gaťek, Jiří (referee) ; Šiller, Jiří (referee) ; Jandík, Pavel (referee)
Introduction: Breast cancer still remains the most common malignancy in women and its incidence is slowly increasing. A marked reduction of mortality has been achieved in the last 10 years thanks to modern diagnostic methods, mammary screening, and comprehensive and targeted cancer therapy. Modern diagnostic capabilities not only allow early diagnosis of a primary tumor lesion and precise determination of its biological nature before commencing treatment, but they also enable early diagnosis of local and regional recidives, including diagnosis of metastases in distant organs. In addition to clinical examination, conventional and complementary imaging examinations and tumor markers our objective was to determine the importance and use of growth factors in relation to the overall prognosis. The growth factors physiologically act already during the ontogenetic period when they control cell growth, proliferation, differentiation and apoptotic processes. It is known that they take part in the tumor growth processes which are characterized by autonomous behavior, increased proliferative activity, distinct differentiation activity and reduced apoptosis. Growth factors work as autoregulation factors in the neoplastic process as well as through their paracrine effects mediated by more or less specific receptors....
|
guest ::
