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Osmolality of Parenteral Preparations. Calcium Chloride
Fraňková, Alena ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate Mgr. Alena Fraňková Consultant Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Title of Thesis Osmolality of parenteral preparations. Calcium chloride. Knowledge of osmotic concentration of the solution is necessary for the safe application of the large-volume parenteral product. In this work, osmolality and the density of molal and molar aqueous solutions of calcium chloride hexahydrate in a concentration range of 20 - 1000 mmol/kg, and/or mol/l, respectively, were measured. The density of the solution was directly proportional to its concentration. The non-linear dependence of the density on temperature was described by the quadratic regressions with coefficients of determination in a range of 0,9997 - 1,0000. The average density of solutions at 20 řC was used in the mutual interconversion between molality and molarity. A linear dependence was found between molality and molarity of calcium chloride hexahydrate solutions. Three methods of estimation of osmolarity (mosmol/l) of the calcium chloride hexahydrate solutions were studied and the results were compared with the experimentally determined osmolality (mosmol/kg). Out of them, the most accurate values of osmolarity provided a method...
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Osmolality of parenteral preparations. Magnesium chloride.
Fraňková, Alena ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of Pharmaceutical Technology Consultant: PharmDr. Zdeňka Šklubalová, Ph.D. Student: Alena Fraňková Title of Thesis: Osmolality of parenteral preparations. Magnesium chloride. Application of parenteral infusions requires knowledge of the osmotic concentration of solutions. In this work, osmolality was measured and the influence of temperature on the density of aqueous solutions of magnesium chloride hexahydrate prepared in molal and molar concentrations ranging from 0,02 to 1,0 mol/kg and/or mol/l, respectively, was investigated. The density is directly proportional to the concentration of the solution. The dependence of a density on temperature was described by the quadratic regressions with the coefficients of determination in the range of 0,9993 - 1,0000. A knowledge of the solution density at 20 řC is required for interconversion between molality and molarity of the solution. The linear regression was generated for the mutual conversion between molality and molarity of magnesium chloride hexahydrate solutions. In the second part of this work, the experimentally measured osmolality (mosmol/kg) were compared with osmolarity (mosmol/l). Out of three different methods studied, the values of the theoretical osmolarity...
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Annotated Translation: Jeux mathématiques et vice versa (2017, Paris, pp. 33-85)
Franková, Alena ; Duběda, Tomáš (advisor) ; Šotolová, Jovanka (referee)
The bachelor thesis is divided into two parts. The first part consists of the translation from French to Czech language, the second part contains the commentary. Selected parts of the popular science book Jeux mathématiques et vice versa written by four French mathematicians: Gilles Dowek, Jean-Pierre Bourguignon, Jean-Christophe Novelli a Benoît Rittaud are translated. The commentary includes the translation analysis of the text, based on which the concept of translation is determined. Furthermore, the problems, which has occurred during the process of translation, are presented in conjunction with the solutions and their examples.
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Osmolality of Parenteral Preparations. Calcium Chloride
Fraňková, Alena ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate Mgr. Alena Fraňková Consultant Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Title of Thesis Osmolality of parenteral preparations. Calcium chloride. Knowledge of osmotic concentration of the solution is necessary for the safe application of the large-volume parenteral product. In this work, osmolality and the density of molal and molar aqueous solutions of calcium chloride hexahydrate in a concentration range of 20 - 1000 mmol/kg, and/or mol/l, respectively, were measured. The density of the solution was directly proportional to its concentration. The non-linear dependence of the density on temperature was described by the quadratic regressions with coefficients of determination in a range of 0,9997 - 1,0000. The average density of solutions at 20 řC was used in the mutual interconversion between molality and molarity. A linear dependence was found between molality and molarity of calcium chloride hexahydrate solutions. Three methods of estimation of osmolarity (mosmol/l) of the calcium chloride hexahydrate solutions were studied and the results were compared with the experimentally determined osmolality (mosmol/kg). Out of them, the most accurate values of osmolarity provided a method...
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Osmolality of parenteral preparations. Magnesium chloride.
Fraňková, Alena ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of Pharmaceutical Technology Consultant: PharmDr. Zdeňka Šklubalová, Ph.D. Student: Alena Fraňková Title of Thesis: Osmolality of parenteral preparations. Magnesium chloride. Application of parenteral infusions requires knowledge of the osmotic concentration of solutions. In this work, osmolality was measured and the influence of temperature on the density of aqueous solutions of magnesium chloride hexahydrate prepared in molal and molar concentrations ranging from 0,02 to 1,0 mol/kg and/or mol/l, respectively, was investigated. The density is directly proportional to the concentration of the solution. The dependence of a density on temperature was described by the quadratic regressions with the coefficients of determination in the range of 0,9993 - 1,0000. A knowledge of the solution density at 20 řC is required for interconversion between molality and molarity of the solution. The linear regression was generated for the mutual conversion between molality and molarity of magnesium chloride hexahydrate solutions. In the second part of this work, the experimentally measured osmolality (mosmol/kg) were compared with osmolarity (mosmol/l). Out of three different methods studied, the values of the theoretical osmolarity...
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