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Differences in the auxological characteristics of children with short stature - differential diagnostic possibilities of hypothyreosis
Daniš, Robert ; Zamrazilová, Hana (referee)
Child growth is a multifactorial process combining the influence of the polygenic form of inheritance and the influence of the environment in which the child grows up. The socio- economic level of the state and family is a determining factor in the rate of use of genetic growth potential. During the 20th century, the living conditions improved and the average population height increased, so-called secular changes. Negative trends in the lifestyle of today's society tend to grow rather restrictively. The sedentary lifestyle, along with the prevalence of overweight and obesity in current children, changes their growth profile, especially during puberty, and turns the secular trend of the height in the opposite direction. Growth is also a sensitive indicator of the health condition of a child. Serious diseases of the chronic and systemic character inhibit growth. Growth retardation also develops in some endocrinopathies, particularly in growth hormone deficiency and thyroid hormone deficiency. The auxological picture of these diseases is very similar. Differential marker is the only difference in the severity of delay ossification of carpal bones and long bones when assessing bone age from the X-ray of the hand and the distal forearm. The diagnostic logistic regression model, based on the definition...
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Differences in the auxological characteristics of children with short stature - differential diagnostic possibilities of hypothyreosis
Daniš, Robert ; Zamrazilová, Hana (referee)
Child growth is a multifactorial process combining the influence of the polygenic form of inheritance and the influence of the environment in which the child grows up. The socio- economic level of the state and family is a determining factor in the rate of use of genetic growth potential. During the 20th century, the living conditions improved and the average population height increased, so-called secular changes. Negative trends in the lifestyle of today's society tend to grow rather restrictively. The sedentary lifestyle, along with the prevalence of overweight and obesity in current children, changes their growth profile, especially during puberty, and turns the secular trend of the height in the opposite direction. Growth is also a sensitive indicator of the health condition of a child. Serious diseases of the chronic and systemic character inhibit growth. Growth retardation also develops in some endocrinopathies, particularly in growth hormone deficiency and thyroid hormone deficiency. The auxological picture of these diseases is very similar. Differential marker is the only difference in the severity of delay ossification of carpal bones and long bones when assessing bone age from the X-ray of the hand and the distal forearm. The diagnostic logistic regression model, based on the definition...
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Quantification of differences in ossification zones hand TW3 method in patients with hypothyroidism - the possibility of diagnostic use
Daniš, Robert ; Sedlak, Petr (advisor) ; Čermáková, Ivana (referee)
The assessment of the development of skeletal maturation is an essential diagnostic tool in many pediatric disciplines, especially in pediatric endocrinology. The most accurate method of estimating bone age (KV) is a method of Tanner-Whitehouse 3 (TW3), which separately evaluates compartments RUS and CARP, the ossification is controlled by different hormonal axes. While the file type of long bones (metacarpals, phalanges of fingers and distal epiphysis of the radius and ulna - system RUS) is under the dominant influence of somatotropic axis, in the regulation of the development of carpal bones (system CARP) dominates the influence of thyroid axis. The proportionality developmental retardation of the two compartments from the chronological age can directly show the suspected endocrine cause of growth and developmental disorder. The study included 48 patients with subclinical form of hypothyroidism or in eufunctional status and a reference group of 65 patients with idiopathic growth hormone deficiency and 53 children with constitutional delay of growth and development. All patients were from pediatric ambulances of the Institute of Endocrinology in Prague, ranging in age from 4-18 years. Differences were observed in the value of KV RUS/CARP, height and chronological age and midparental and TW3...
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