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Sterile Place
Bražina, Jan ; Lukáš,, Hofmann (referee) ; Ambrůz, Jan (advisor)
The bachelor's thesis deals with the study of the boundary between man, the supernatural and the object. The resulting spatial installation and video follow the relationship between the human body and the jwho "inhuman accessories".
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love rhymes with fuck you
Bražina, Jan ; Pěchouček, Michal (referee) ; Mazanec, Martin (advisor)
In my work I materialize personal experiences, memories and ideas about future life. In relation to these, I also address the heteronormativity of relationships dictated by society to young people. In my work I deal with these themes through intuitive work with textiles, where I try to express through this material my feelings, in which I tend to a domestic and peaceful background. Over the past year I have begun a project that originally titled Hydroponic Love, in which I dealt with my own failures in relationships and building a bond with inanimate objects in order to satisfy my desire for love. Through this stage I gradually developed my theme and elaborated on the idea of love that ...that can develop into a dangerous obsession. The project eventually expanded into four parts, in in which I developed several sub-themes that no longer focused on my personal desires and failures, but also the broader social context related to them.
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Posttranslational modification of the adapter protein DAXX in the cellular response to genotoxic stress
Bražina, Jan ; Anděra, Ladislav (advisor) ; Černý, Jan (referee) ; Vodička, Pavel (referee)
Maintaining the chromosome continuity and complete genetic information in human cells is crucial for cell survival and the whole organism. It prevents life-threatening pathologies and preserves genetic continuity. However, cellular DNA is exposed to both endogenous and exogenous stress damaging its content and integrity. This stress activates mechanisms involving detection and repair of these damaged sites (DDR). One of the most serious types of DNA damage double-stranded breaks (DSB) occuring when both strands are severed. DSBs trigger wave of PTMs that regulate protein interactions, nuclear localization and catalytic activity of hundreds of proteins. Such modifications include acetylation, methylation, SUMOylation, ubiquitinylation and especially phosphorylation. The most important kinases involved in DDR kinases are ATM, ATR and DNA-PK. These kinases are activated immediately after the detection of the damaged area. DAXX (Death-associated protein 6) is an adapter and predominantly nuclear protein, which is involved in chromatin remodeling, gene expression modulation, antiviral response and depositing histone H3.3 variants into chromatin or telomeres. Daxx is essential for murine embryogenesis, since the homozygous deletion is lethal in E9.5-10. In 2006 a study mapping the substrates of kinases...
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Sterile Place
Bražina, Jan ; Lukáš,, Hofmann (referee) ; Ambrůz, Jan (advisor)
The bachelor's thesis deals with the study of the boundary between man, the supernatural and the object. The resulting spatial installation and video follow the relationship between the human body and the jwho "inhuman accessories".
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Posttranslational modification of the adapter protein DAXX in the cellular response to genotoxic stress
Bražina, Jan ; Anděra, Ladislav (advisor) ; Černý, Jan (referee) ; Vodička, Pavel (referee)
Maintaining the chromosome continuity and complete genetic information in human cells is crucial for cell survival and the whole organism. It prevents life-threatening pathologies and preserves genetic continuity. However, cellular DNA is exposed to both endogenous and exogenous stress damaging its content and integrity. This stress activates mechanisms involving detection and repair of these damaged sites (DDR). One of the most serious types of DNA damage double-stranded breaks (DSB) occuring when both strands are severed. DSBs trigger wave of PTMs that regulate protein interactions, nuclear localization and catalytic activity of hundreds of proteins. Such modifications include acetylation, methylation, SUMOylation, ubiquitinylation and especially phosphorylation. The most important kinases involved in DDR kinases are ATM, ATR and DNA-PK. These kinases are activated immediately after the detection of the damaged area. DAXX (Death-associated protein 6) is an adapter and predominantly nuclear protein, which is involved in chromatin remodeling, gene expression modulation, antiviral response and depositing histone H3.3 variants into chromatin or telomeres. Daxx is essential for murine embryogenesis, since the homozygous deletion is lethal in E9.5-10. In 2006 a study mapping the substrates of kinases...
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Archaeological parks and archaeological open-air museum in the Czech republic
Bražina, Jan ; Novák, Zdeněk (advisor) ; Tyslová, Irena (referee)
The way of presenting of both tangible and intangible cultural heritage has undergone a dramatic change during the last century. It has shifted from the simple displaying of inanimated artefacts towards an interactive link between the artefact and the visitor. Moreover, cultural heritage exhibitions are no more a matter exclusive for traditional museums. Archaeological open-air museums as well as archeological parks became a very suitable platform for presenting cultural heritage as they combine several approaches: experimental archaelogy, reconstruction and living history. Besides this effective didactics are these institutions significant in supporting the tourist industry as well. The aim of this work is to analyze both the educational and economic potencial of these institutions situated in the Czech republic. Some of the possible management risks are briefly mentioned in the end.
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