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Recent trends in therapy of diabetes mellitus type II
Boučková, Karolína ; Herink, Josef (advisor) ; Vopršalová, Marie (referee)
The bachelor's thesis is adressed to diabetes mellitus type 2, the lifestyle disease. It characterizes all its kinds, the laboratory diagnostics and complications. The thesis also contains causes of its appereance, risk factors and clinical manifestations. Nowadays the disease is growing enormously, it strikes people of different ages and genders. That is why the selection of therapy is very important. Particular attention is paid to a standart therapy but also to the latest trends within pharmacological and non-pharmacological treatments. Thanks to suitable therapy and upholding the treatment plan patients can live their life to the full. Key words: diabetes mellitus type 2, clinical symptoms, therapy
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MicroRNA regulation of glutathion peroxidases
Boučková, Karolína ; Matoušková, Petra (advisor) ; Skarková, Veronika (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Science Candidate: Bc. Karolína Boučková Supervisor: doc. Ing. Petra Matoušková, Ph.D. Title of diploma thesis: MicroRNA regulation of glutathion peroxidases Oxidative stress is an imbalance between the formation of free radicals and the organism's ability to remove those radicals naturally. There can be cell and DNA damage, premature aging, the emergence of various diseases if there is an excessive production of free radicals in the body and they are not scavenged. However, free radicals are also beneficial for the body, as it uses them to remove dead cells and bacteria. Normally, the organism has enough mechanisms to compensate for the activity of free radicals and prevent oxidative stress. Antioxidants can inhibit the activity of free radicals. They are divided into enzymatic and non-enzymatic antioxidants. The most important enzymatic antioxidants are glutathione peroxidases (GPx). Eight genes encoding GPx have been discovered in the human genome. GPx is a cytosol enzyme that catalyzes the reduction of hydrogen peroxide to water and oxygen, as well as it catalyzes the reduction of peroxide radicals to alcohols and oxygen. The reduction of expression or inactivation of enzymes may pose danger to the organism....
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MicroRNA regulation of glutathion peroxidases
Boučková, Karolína ; Matoušková, Petra (advisor) ; Skarková, Veronika (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Science Candidate: Bc. Karolína Boučková Supervisor: doc. Ing. Petra Matoušková, Ph.D. Title of diploma thesis: MicroRNA regulation of glutathion peroxidases Oxidative stress is an imbalance between the formation of free radicals and the organism's ability to remove those radicals naturally. There can be cell and DNA damage, premature aging, the emergence of various diseases if there is an excessive production of free radicals in the body and they are not scavenged. However, free radicals are also beneficial for the body, as it uses them to remove dead cells and bacteria. Normally, the organism has enough mechanisms to compensate for the activity of free radicals and prevent oxidative stress. Antioxidants can inhibit the activity of free radicals. They are divided into enzymatic and non-enzymatic antioxidants. The most important enzymatic antioxidants are glutathione peroxidases (GPx). Eight genes encoding GPx have been discovered in the human genome. GPx is a cytosol enzyme that catalyzes the reduction of hydrogen peroxide to water and oxygen, as well as it catalyzes the reduction of peroxide radicals to alcohols and oxygen. The reduction of expression or inactivation of enzymes may pose danger to the organism....
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Recent trends in therapy of diabetes mellitus type II
Boučková, Karolína ; Herink, Josef (advisor) ; Vopršalová, Marie (referee)
The bachelor's thesis is adressed to diabetes mellitus type 2, the lifestyle disease. It characterizes all its kinds, the laboratory diagnostics and complications. The thesis also contains causes of its appereance, risk factors and clinical manifestations. Nowadays the disease is growing enormously, it strikes people of different ages and genders. That is why the selection of therapy is very important. Particular attention is paid to a standart therapy but also to the latest trends within pharmacological and non-pharmacological treatments. Thanks to suitable therapy and upholding the treatment plan patients can live their life to the full. Key words: diabetes mellitus type 2, clinical symptoms, therapy
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