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Monitoring of liberation tests.
Beran, Marek ; Sklenářová, Hana (advisor) ; Matysová, Ludmila (referee)
Charles University Faculty of Pharmacy in Hradci Králové Department of Analytical Chemistry Candidate: Marek Beran Supervisor: Doc. PharmDr. Hana Sklenářová, Ph.D. Consultant: Ing. Daniela Šmejkalová, Ph.D Title of Diploma Thesis: Monitoring of liberation tests The diploma thesis is focused on the development of an automated method for the monitoring of the dissolution profile of clotrimazole from topical dosage forms. The dissolution profile of formulations containing the antifungal agent clotrimazole are compared. Commercially available formulations Canesten and Clotrimazol AL in the form of creams, are compared with a new formulation called Delcore from Contipro a.s., which contains a complex matrix. Theoretical part addresses mycotic infections with focus on superficial mycoses and products available on the Czech market for the treatment of those infections. Furthermore, there is a description of selected non-separation flow methods. The analysis was carried out in a sequential injection analysis system coupled with three attached Franz dissolution cells with a membrane on which the sample was applied. The Franz cells were placed in a water bath at 32 řC. Phosphate buffer with pH 7.4 was chosen as the dissolution medium as it partially imitates the conditions of the human environment. Detection...
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Monitoring of liberation tests.
Beran, Marek ; Sklenářová, Hana (advisor) ; Matysová, Ludmila (referee)
Charles University Faculty of Pharmacy in Hradci Králové Department of Analytical Chemistry Candidate: Marek Beran Supervisor: Doc. PharmDr. Hana Sklenářová, Ph.D. Consultant: Ing. Daniela Šmejkalová, Ph.D Title of Diploma Thesis: Monitoring of liberation tests The diploma thesis is focused on the development of an automated method for the monitoring of the dissolution profile of clotrimazole from topical dosage forms. The dissolution profile of formulations containing the antifungal agent clotrimazole are compared. Commercially available formulations Canesten and Clotrimazol AL in the form of creams, are compared with a new formulation called Delcore from Contipro a.s., which contains a complex matrix. Theoretical part addresses mycotic infections with focus on superficial mycoses and products available on the Czech market for the treatment of those infections. Furthermore, there is a description of selected non-separation flow methods. The analysis was carried out in a sequential injection analysis system coupled with three attached Franz dissolution cells with a membrane on which the sample was applied. The Franz cells were placed in a water bath at 32 řC. Phosphate buffer with pH 7.4 was chosen as the dissolution medium as it partially imitates the conditions of the human environment. Detection...
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Empirical analysis of patterns of acquired companies
Kachlík, Brian ; Rýdlová, Barbora (advisor) ; Beran, Marek (referee)
Announcements of acquisitions of publicly traded companies are usually accompanied by their share price booming by tens of percent. The underlying reason is that the acquirer of the company gains a controlling stake, due to which he can help the company pivot in the desired direction or benefit from synergy effects. A minority investor, by definition, is not capable of doing this, thus he is willing to pay a lower price for the shares than the acquirer of the controlling stake. The thesis analyzes whether a minority shareholder can profit from the acquisition premium by purchasing shares of companies which he believes will be later acquired. The paper consists of two parts - theoretical and analytic. The theoretical part discusses the significance of the acquisition premium and its value, with regard to the type of investor and his motivations for the acquisition. The theoretical part yields into the analytic part, where acquisition waves are tested. It also includes an analysis of individual acquisitions and their underlying reasons, which are grouped into categories in order to find patterns of aquired companies.
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Tools of strategic management in AIESEC Praha
Angelovič, Juraj ; Matyáš, Ondřej (advisor) ; Beran, Marek (referee)
The aim of my thesis is to critically evaluate the set of management tools used in the student organization AIESEC Praha. The issues discussed are the organization's mission and strategic management, especially using the system of Balanced Scorecard. Furthermore, terms of critical success factors and key performance indicators are defined and are being investigated in various stages of development of the strategic map of Balanced Scorecard of AIESEC Praha, with emphasis on their annual change, consistency and coherence with other instruments of the organization, its internal development and the development of the external environment. In conclusion I describe a draft of qualitatively better system of management tools of AIESEC Praha with regard to described objectives. Emphasis is also placed on the conditions of usage of the system of management tools and the factors that influence its further development.
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Forecast sources for selected individual industries for business valuation purposes
Navrátil, David ; Maříková, Pavla (advisor) ; Beran, Marek (referee)
The aim of this thesis is to identify and according to selected criteria to evaluate the forecast sources for selected individual industries. The first section summarizes current situation in area of forecast sources for development of individual sectors. The second part presents outline of procedure for forecast sources identification and research. Then follows selection of individual industries that will be analyzed. Part of the second section is introduction of the evaluation criteria as well as methodology for the final assessment. Third part of the thesis is focused on practical work consisting of identification and searching for the sources for individual industries, their detailed evaluation based on established criteria and final assessment of individual sources for each sector. Third part is followed by summary and description of the findings and recommendations.
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Key performance indicators of private equity
Beran, Marek ; Krabec, Tomáš (advisor) ; Fous, Zdeněk (referee)
This thesis aims to identify key performance indicators of private equity. At the beginning of the paper are defined both parts of private equity, criterias of each part and relationships among market participants. It is then outlined the history of the two main parts. In the next step is introduced global development with emphasis on the last 30 years. A larger space is then devoted to Europe, which will subsequently be a pivotal part of the work. Following this section is indicated methodology. In the next section is defined 7 countries, which are subsequently subjected to research. The fourth chapter is an empirical survey of individual States, Czech Republic, Great Britain, Poland, Sweden, Romania, Singapore and France, where are mentioned results of evaluated factors and also the defending of values. The last, fifth, is itself part of the evaluation and comments on results achieved.
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Financial decisions in AIESEC
Beran, Marek ; Zouhar, Tomáš (advisor) ; Mydlo, Jaroslav (referee)
Goal of this thesis is to compile ideal budget, which is done through Balance Scorecard, that adjusted to non-for profit organisation. I tried to show the biggest differencies between corporate organisation and non-for profit organisation. Whole model was applied on local committee of non-for profit organisation
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