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The value of the Child's Wish in the Contemporary Pracities of the Proceedings Regardiny the Adjustment of Legal Relations towards Minor Children
Böhmová, Tereza ; Žáčková, Hana (advisor) ; Mlejnková, Kristýna (referee)
This Diploma Thesis is focused on the issue of the value of a child's wish in the framework of the divorce/break-up settlement. In the theoretical part of this thesis, the child's status, its right to participate and the means of ensuring that in the mentioned framework are presented. In this thesis, the term child's wish is also discussed in the context of defending child's own interest. In the last chapter of the theoretical part, there is illustrated the suitable way how to interview a child. The aim of the practical part is to, through half-structured interviews with the professionals taking part in this process and an analysis of those interviews, answer the main research question: How do the professionals taking part in the divorce/break-up settlement perceive and deal with the child's wish in this process? The research part of this thesis is also focused on the possible space for change in the contemporary attitude towards children as participants of trials.
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Regulation of PKB/AKT phosphorylation during resumtion of meiosis
Böhmová, Tereza ; Krylov, Vladimír (referee) ; Šolc, Petr (advisor)
PI3K-PKB signal pathway participates in the CDK1 activation, which is necessary for meiosis resumption of mouse oocytes. That's why we wanted to examine the role of PKB in this process more in the details. The activity of PKB is associated with its phosphorylation at Thr308 and Ser473. These phosphorylations are probably independent and influence PKB function. Thr308 phosphorylated PKB is implicated in resumption of meiosis (GVBD), whereas Ser473 phosporylation is not - as oocytes with reduced phosphorylation on Thr308 have delayed GVBD kinetics and oocytes with inhibited phosphorylation of Ser473 reinitiate meiosis comparably to control oocytes. Conversely, oocyte treatment with synthetic biologically active PtdIns(3,4,5)P3 leads to stronger phosphorylation at Thr308 and accelerated GVBD kinetics. It was also found, that the kinase responsible for Ser473 phosphorylation in mouse oocytes is ATM. Powered by TCPDF (www.tcpdf.org)
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