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Comparasion of interaction of cyanidin and cyanidin-3-glucoside with copper and iron
Gavurová, Lucie ; Mladěnka, Přemysl (advisor) ; Smutná, Lucie (referee)
Iron and copper are trace elements involved in many essential processes in the human body. Copper plays an important role in human metabolism, primarily as a cofactor of many metalloenzymes, like superoxide dismutase and ceruloplasmin. Copper is also essential for iron homeostasis. Iron is incorporated into many biomolecules like heme or enzymes, and is hence vital for cellular processes like oxygen transport, energy production and DNA synthesis. In biological systems, copper is present in both the oxidised form of cupric (Cu2+ ), and the reduced form as cuprous ion (Cu+ ). Iron as well exists in two stable oxidation states as ferrous (Fe2+ ) or ferric ion (Fe3+ ). Due to their strong redox potential, both elements can be potentially toxic to the body. Iron accumulates in vital organs such as the liver, heart and kidneys. Wilson's disease is an example of copper overload disease resulting from pathogenic mutations in gene ATP7B. The iron excess in the body is usually associated with iron overloading conditions, such as hereditary hemochromatosis or repeated treatments with blood transfusions (e.g. in thalassemia). In such cases, drugs with chelating or reducing effect are convenient for clinical use. The aim of this thesis was to compare the interaction of the chelating and reducing efficacy of two...
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