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Effect of anthelmintics on expression of selected plant enzymes
Navrátilová, Martina ; Matoušková, Petra (advisor) ; Novotná, Eva (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Martina Navrátilová Supervisor: Ing. Petra Matoušková, Ph.D. Title of diploma thesis: Effect of anthelmintics on expression of selected plants enzymes Fenbendazole (FEN) is a broad-spectrum benzimidazole anthelmintic that is widely used to prevent and treat helminthoses in farm animals. The use of anthelmintics is associated with the risk of their transfer to the environment, where they can potentially affect non-target organisms, including plants. They come into contact with anthelmintics and their metabolites mainly due to the fertilization of farmland with manure and/or come directly into contact with the excrements of treated animals on pastures. There have not been many studies focused on the cell physiology and cell metabolism of plants affected by anthelmintics, which lead to our participation in a study which dealt, in part, with the influence of FEN on the transcriptome and gene expression in model plant Arabidopsis thaliana. A. thaliana is a monocotyledonous plant, which is a very common model organism of higher plants. Its genome was also published in 2000, allowing extensive research into gene expression. The aim of this work was to monitor expression of selected A....
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