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Eye diseases and color discrimination
Huňa, Lukáš ; Hornová, Jara (advisor)
More than 100 years we know the typical changes of the optic nerve and visual field defects in patients with glaucoma. Despite our knowledge at that time well advanced, accurate pathogenesis of this disease still remains a mystery. In the present he is at the forefront of efforts to identify such tests visual functions, which revealed damage to nerve fibers before loss of vision. Such tests offer the possibility color perception, which were used in the empirical part of the thesis, where she studied the dependence on changes in color perceptiondisorders visual field arising in connection with primary glaucoma
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Důsledky zavedení a zrušení regulačních poplatků ve zdravotnictví ČR
Kölbl, Martin
This thesis is focused on issues with increased financial participation of patients in Czech health care, which was established by implementation of regulatory fees in 2008. Their reason was decrease overuse of health care and influx of financial sources to the health care. In the empirical analysis impacts of regulatory fees were examined by testing the average values of selected indicators before and after their implementation. Inpacts of cancelled regulatory fees are ilustrated on the compared average values of selected indicators when they were used and after they were cancelled. Another goal of the thesis is based on the relevant literary sources study and executed analysis propose changes of financial participation in health care of Czech Republic.
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název v anglickém jazyce není uveden
Klusáčková, Pavlína ; Pelclová, Daniela (advisor) ; Hajduková, Zdeňka (referee) ; Vízek, Martin (referee)
Early diagnosis of occupational asthma is important especially for the prognosis of this disease. The confirmation of the diagnosis of occupational asthma is sometimes difficult using diagnostic methods available nowadays. That is why searching new methods is very important. Analysis of exhaled breath condensate (EBC) by liquid chromatography combined with mass spectrometry enables the separate detection of cysteinyl leukotrienes (LT) - LTC4, LTD4, LTE4; LTB4 and 8-isoprostane. If patients with occupational asthma and controls were compared, only LTC4 was significantly higher among all EBC parameters studied in asthmatics (despite corticosteroid treatment). This marker could be used in the future diagnostics. Monitoring of 24-hours variability of EBC parameters in patients, in whom occupational asthma is suspected, showed relatively high intraindividual and interindividual variation. It is evident therefore, that if only one daily measurement in asthmatics would be possible (which is common in articles of several authors), it should be collected in the same period of day in all persons. In negative bronchoprovocation tests significant changes of EBC parameters were not found. The evaluation of positive bronchoprovocation tests was limited by small number of patients, however in five persons from six, the...
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Stress-strain analysis of arterial aneurysms
Tesařová, Petra ; Skácel, Pavel (referee) ; Burša, Jiří (advisor)
The diploma thesis is focused on the creation of the aneurysm finite element model and the making of the aneurysm wall stess-strain analysis using ANSYS software. The model of abdominal aortic aneurysm geometry starts from the CT scan of the particular patient. In the thesis there are compared two chosen constitutive models, each of them appears from different mechanical tests done on human arterial fibre samples. Furthermore, a limiting condition for aneurysm wall structure damage is expressed. On the basis of the results of stress calculation in the aneurysm wall and the limiting condition, the safety coefficient and rupture factors risk are worked out.
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Agression measurement and assessment using methods of psychological diagnostics
Harsa, Pavel ; Žukov, Ilja (advisor) ; Hynek, Karel (referee) ; Kratochvíl, Stanislav (referee)
We have tried in doctoral thesis to objectively verify usability of questionnaires and projective methods in evaluation of aggressiveness of psychiatric patients. In the theoretical part of the study we discuss definitions of aggression and aggressiveness. There is a number of theoretic interpretations of aggressiveness and aggression in which these general terms are characterized. Most authors and single theory are in full agreement of views that there are two types of aggression, aceptable and unacceptable for society. We have aimed at bio-psycho-social aspects of aggression and the structure of aggressive personality. Nowadays there are many branches of science, which are engaged in aggressiveness, for example genetics, biology and psychology. It is evidence to support the view that aggressiveness is a serious problem in human society. At the same timee it is difficult to find empiric assessment of aggression. (...) In conclusion: These results verify clinical and forensic experience with assessment and measurement of aggressiveness. Test methods show much more general temperament dispositions, tendency to emotional reaction and to explosive reactions. Information and experience from this thesis could be helpful for assessment of emotional aggression in psychiatric patients and for forensic practie....
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Genetic Aspects of Sporadic Ovarian Cancer
Jančárková, Natalia ; Freitag, Pavel (advisor) ; Rokyta, Richard (referee) ; Kohoutová, Milada (referee)
58 9. SUMMARY Molecular biological parameters, including genetic alterations, present new and perspective direction in diagnostics, prediction of prognosis, monitoring and possible therapeutic approaches in oncological disease. The results presented have to do with the project, which is concentrated upon chromosomal rearrangements in ovarian and cervical cancer and their correlations with available parameters of both molecular biological and clinical characteristics. Sixty patients with ovarian cancer and twenty patients manifesting cervical cancer were included into the study. The histological type and grade, MIB-1 and p53 (using immunohistochemical method) were estimated by histopathologist. Both conventional karyotyping and molecular-cytogenetic methods (fluorescent in situ hybridization and comparative genomic hybridization) were applied to reveal chromosomal aberrations. The results were subjected to statistical evaluation, using analysis of variances and χ2 test. There were correlated parameters of quantitative and qualitative character - age, stage, histological type, grade, CA 125 before and after treatment, MIB-1, p53, surgical residuum, lymphadenectomy, response rate, chromosomal rearrangements. Analyses accomplished in ovarian cancer group revealed typical amplifications on chromosomes 1q, 3q and...
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