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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Larval cestodes and tumors: characterization of antibody response and cross-reactivity
 Vajs, Vojtěch ; Horák, Petr (advisor) ; Panská, Lucie (referee)
In recent years there have been developments in research concerning the effect of certain species of helminths on cancer. For example, a preventative infection with these parasites is capable of slowing or completely preventing the development of certain cancers in experimental models. In our preliminary experiments, the suppressive effect of the infection with Taenia crassiceps and Mesocestoides corti on melanoma cancer cells was discovered. Primary infection with these tapeworms has been able to suppress and completely prevent the growth and metastasis of the B16F10 melanoma cell line. Parasites affect the immune system of their hosts with their presence and products. It was therefore the subject of this work to explore one of the ways how these tapeworms may achieve this effect - cross-reactivity of antibodies with tapeworm and cancer cell antigens. First the antibody response of the mouse organism to the tapeworm infection was examined in C57BL/6J inbred and ICR outbred strains. The growth of immunoglobulin levels was measured with ELISA within the first five weeks post infection, upon which the antigens, with which these immunoglobulins react, were specified with the help of Western blot. After this, these reacting antigens were localised in the tapeworm organism with immunohistochemical...
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Alergeny v potravinách
 Vlková, Veronika
This thesis focuses on the major allergens in food that are dangerous for allergic individuals. Currently eight major allergenic foods are known but still new allergenic foods are added to the list. The thesis describes characteristic of these allergens including the structure and stability to various factors. Allergenic potential of the additives is mentioned. The thesis also includes information about essential functions of the immune system and its components. It explains the classification of negative reactions to food and their basic mechanisms. One chapter is devoted to food allergy symptoms, which appear after consumption of food containing allergens. It also presents the topic of cross-reaction and the major food allergens detection methods. Due to the importance of food allergens, scientists try to harmonization of detection of these allergens all over the world. In conclusion, the thesis provides information about labeling of food allergens.
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