|
|
Renovation of the castle in Velké Němčice
Strašáková, Anna ; Muroň, Ivo (referee) ; Ležatka, Lukáš (advisor)
The subject of the bachelor thesis is the preparation of the documentation for the building permit and part of the documentation for the implementation of the building on the basis of the architectural study, which was developed in the subject AG35 (monument restoration studio). The theme of this bachelor thesis was to find a suitable concept for a new functional use, taking into respect the historical nature of the monument and its structural and technical condition. The project included the restoration of the whole area of the castle, for leisure use and the addition of parking spaces. The result was an architectural study of the restoration with an emphasis on viability and feasibility. The aim of the bachelor's thesis is the gentle restoration of the building with an emphasis on its reuse with both new functions and elements. The castle has been enriched with an extension that adds more lively proportions, thanks to a stained glass window designed in the shape of a crutch, which is the emblem of the municipality of Velké Němčice. The chateau is designed to function as an office, but also as a rental space, a clubhouse, a library, exhibition space and ceremonial rooms. The entire building is designed to be wheelchair accessible, including the immediate surroundings of the castle.
|
|
|
Research of vitreous and vitreoretinal interface in microvascular retinal disorders focussed on eye complications of diabetes mellitus
Křížová, Libuše ; Zima, Tomáš (advisor) ; Průša, Richard (referee) ; Sosna, Tomáš (referee)
In this work I present conclusions of clinical-laboratory research focused on the patients with diabetic macular edema (DME). We performed biochemical and immunochemical analyses of vitreous samples that were collected during the pars plana vitrectomy. Moreover, at patients with non-proliferative diabetic retinopathy (NPDR) we assessed morphological characteristics of DME using optical coherence tomography (OCT). According to our findings, the vitreous and serum concentrations of uric acid and glucose were significantly higher in patients with diabetic retinopathy and DME compared to controls. Also total ratio (serum/ vitreous concentration) of uric acid and glucose was in diabetics significantly higher than in controls. The most important determinant of increasing concentration of both uric acid and glucose in the vitreous was the grade of diabetic retinopathy. Moreover, we demonstrated significant correlation between vitreous concentration of uric acid and concentration of the vascular endothelial growth factor (VEGF) in patients with DME and NPDR. We found further, that the volume of the macula (cube volume - CV) computed with the software of Cirrus HD-OCT correlates in diabetics significantly with the vitreous VEGF concentration, but not with uric acid. This OCT parameter could be used to...
|
|
|
Research of vitreous and vitreoretinal interface in microvascular retinal disorders focussed on eye complications of diabetes mellitus
Křížová, Libuše ; Zima, Tomáš (advisor) ; Průša, Richard (referee) ; Sosna, Tomáš (referee)
In this work I present conclusions of clinical-laboratory research focused on the patients with diabetic macular edema (DME). We performed biochemical and immunochemical analyses of vitreous samples that were collected during the pars plana vitrectomy. Moreover, at patients with non-proliferative diabetic retinopathy (NPDR) we assessed morphological characteristics of DME using optical coherence tomography (OCT). According to our findings, the vitreous and serum concentrations of uric acid and glucose were significantly higher in patients with diabetic retinopathy and DME compared to controls. Also total ratio (serum/ vitreous concentration) of uric acid and glucose was in diabetics significantly higher than in controls. The most important determinant of increasing concentration of both uric acid and glucose in the vitreous was the grade of diabetic retinopathy. Moreover, we demonstrated significant correlation between vitreous concentration of uric acid and concentration of the vascular endothelial growth factor (VEGF) in patients with DME and NPDR. We found further, that the volume of the macula (cube volume - CV) computed with the software of Cirrus HD-OCT correlates in diabetics significantly with the vitreous VEGF concentration, but not with uric acid. This OCT parameter could be used to...
|
guest ::
