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The use of electrochemistry for the study of human metabolism of sulfur-containing compounds
Navrátil, Tomáš ; Petr, M. ; Šenholdová, Z. ; Přistoupilová, K. ; Přistoupil, T. I. ; Heyrovský, Michael ; Pelclová, D. ; Kohlíková, E.
The contribution deals with explanation of metabolism of supplemented creatine in human organism. This process differs from metabolism of natural endogenous creatine, which is excreted in form of creatinine. Exogenous creatine induces increase of peptide formation, of body mass, and of intracellular fluid; from 4 to 6 hours after creatine supplementation the level of thiodiglycolic acid and pH in urine rapidly increase, both of them then decrease rapidly to the original values.
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Creatine fortification in relation to homocysteinemia
Kohlíková, E. ; Petr, M. ; Šenholdová, Z. ; Navrátil, Tomáš ; Heyrovský, Michael ; Přistoupilová, K. ; Přistoupil, T. I.
Some people supplement their diet by high doses of creatine (CR) to increase their muscle performace. In this way, they intensify the biochemical processes on cell membranes. The water thus formed is retained in the cells, which increases the body mass. The organism must remove exogenously added CR, probably in a similar way as in removing xenobiotics via oxidation with cyt.P450 to 2C units to cooperation with GSH. Our new simple and cheap voltammetric method enables to estimate thiogycolic (TDGA), the natural product of oxidative catabolism of thiocompounds, excreted to urine in regular catabolic processes.
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Different metabolic pathwazy of the origin of hyperhomosysteinemia
Přistoupilová, K. ; Přistoupil, T. I. ; Navrátil, Tomáš ; Heyrovský, Michael ; Šenholdová, Z. ; Kohlíková, E. ; Petr, M.
Our voltammetric method of estimation of thiodiglycolic acid (TDGA) in urine was used in case of a woman suffering from rare inborn inability to metylate homocysteine (HoCySH). The aim of this pilot study was to shed more light on the interrelationship among vitamin B.sub.12./sub., folates, and betaine used for her cure. On the basis of the achieved results we were able to modify our earlier published metabolic scheme. It comprises 3 metabolic pathways starting from serine, and three metabolic pathways starting from HoCySH.
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