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Methods for respiration estimates from ECG signal
Mitrengová, Jana ; Mézl, Martin (referee) ; Králík, Martin (advisor)
The thesis deals with the realization of methods for estimation of the respiratory curve from the ECG signal. The first part of the thesis deals with the anatomy and physiology of the respiratory and cardiovascular system. In this part of the thesis are also described ways of the breathing monitoring. The second part of the thesis is dedicated to the description of individual methods for the ECG derived respiration. The third part deals with the realization of selected methods, application of method algorithms on real data and comparison of resulting respiratory curves with the respiratory signals available from the PhysioNet database. In conclusion, the individual methods are compared with each other.
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Modeling of Respiratory System
Matoušek, Josef ; Roleček, Jiří (referee) ; Jiřík, Radovan (advisor)
This thesis is concerned with respiration system simulation. The main goal of this studies is to gain knowledge of how human respiration system works, along with selecting proper algorithms and their implementation into mathematic model. These models are realized by Simulink interface, which is part of Matlab environment. Similar models are used for medical technology research, especially for artificial ventilation of the lungs. There is a practical utilisation of these models suitable for illustration and respiration system's biological processes simulation, particularly combined model described in GUIDE graphic interface - also implemented in Matlab environment.
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PowerCube spirometry measurement
Krajčovič, Martin ; Závodná, Eva (referee) ; Provazník, Ivo (advisor)
This paper is dedicated to the issue of respiratory physiology, human body energy exchange and calorimetry. It describes functions of the PowerCube-Ergo-Device (Ganshorn Medizin Electronic, Germany), which serves ergospirometry measurement and designes a protocol used to measure and evaluate the cardiopulmonary response of the organism and the metabolic activity of the organism in a group of athletes and non-sportspeople. Furthermore, it constitutes an application developed in MATLAB programming environment, allowing graphical portrayal and evaluation of measured data. The final part of this thesis is devoted to statistical evaluation of the data gathered within the selected group of patients.
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Obstructive sleep apnea detection using polysomnography
Smrčková, Markéta ; Mézl, Martin (referee) ; Králík, Martin (advisor)
This thesis attempts to find an alternative method for automatic detection of sleep apnea using polysomnographic data. The first part is focused on introduction to lungs anatomy and physiology of breathing, sleeping and cardiac system. The second part describes the process of sleep examination and particular components of polysomnographic data. The third part is focused on realization of specific method for sleep apnoea detection, application on real data and results evalutation.
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ECG and PPG derived respiration estimation
Chmela, Radek ; Smital, Lukáš (referee) ; Králík, Martin (advisor)
This work deals with the estimation of the respiratory curve from ECG and PPG signals. The first part deals with the description and monitoring of electrical activity of the heart, physiology and methodology of respiratory sensing and photoplethysmography. The second part deals with methods of extracting respiratory cycle information from ECG and PPG recordings. The third part deals with the algorithmic implementation and evaluation of individual procedures for estimating the breath curve from both of the above-mentioned signals on records from the web PhysioNet. In the last part, the algorithms are compared and evaluated.
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Measurement of the respiratory sounds
Gottvald, Martin ; Rychtárik, Milan (referee) ; Kolář, Radim (advisor)
Respiratory sounds measurment This thesis deals with respiratory sounds analysis and measurment using digitalizing measuring cards and LabView environment. The anatomy of respiratory system is described, including each of its fractions and disturbances related to the respiratory system. The design of respiratory sounds amplifier is described, but wasn´t used considering the interferences of measured signal caused by the power-line frequency which results in substantial distortions. That's why, the previously recorded respiratory sounds were used for analysis in Matlab. The measuring program was designed in LabView, which alows signal recording from using acquisition card input and further processing.
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Experimental Research on Aerosol Transport and Deposition in a Human Respiratory Tract
Lízal, František ; Janotková, Eva (referee) ; Adamec, Vladimír (referee) ; Jícha, Miroslav (advisor)
Human health is significantly influenced by inhaled aerosols. Insight to the aerosol transport and deposition mechanisms is a prerequisite for both, toxicological protection against harmful particles and efficient application of inhaled therapeutic aerosols. The purpose of this doctoral thesis was to gain new knowledge of this topic on the basis of in vitro measurements. Phase-Doppler Anemometry was chosen for aerosol transport measurement, for it allows simultaneous measurement of particle size and velocity. Results were processed by means of statistical methods and frequency analysis. Deposition of spherical aerosol particles was measured by Positron Emission Tomography, while deposition of fibrous aerosol was measured by Phase-Contrast Microscopy combined with automated image analysis. All experiments were performed on physical models created on the basis of the real lung geometry. New knowledge of flow characteristics, transition from laminar to turbulent flow, effect of breathing pattern or particle size on aerosol transport and deposition in human lungs are outcomes of this work. Significant effect of the oral cavity was ascertained due to comparison of aerosol deposition in realistic and semi-realistic model with cylindrical smooth walls. Acquired data not merely extended our knowledge of aerosol behavior in lungs but it can also be used for validation of numerical simulations.
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PowerCube spirometry measurement
Krajčovič, Martin ; Závodná, Eva (referee) ; Wilhelm, Zdeněk (advisor)
This paper is dedicated to the issue of respiratory physiology, human body energy exchange and calorimetry. It describes functions of the PowerCube-Ergo-Device (Ganshorn Medizin Electronic, Germany), which serves ergospirometry measurement and designes a protocol used to measure and evaluate the cardiopulmonary response of the organism and the metabolic activity of the organism in a group of athletes and non-sportspeople. Furthermore, it constitutes an application developed in MATLAB programming environment, allowing graphical portrayal and evaluation of measured data. The final part of this thesis is devoted to statistical evaluation of the data gathered within the selected group of patients.
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The effect of the COVID 19 infection on the respiratory and cardiovascular system, physical stress during the course of the disease
Doležalová, Anna ; Heller, Jan (advisor) ; Šteffl, Michal (referee)
Title: Impact of the COVID 19 infection on the respiratory and cardiovascular system, physical strain during the course of the disease Aims: The primary aim of this thesis is to find and study the latest relevant findings regarding the impact of COVID 19 infection on the respiratory system, cardiovascular system and the effect of physical strain on the course of this disease. Subsequently, to write down a critical review on the topic. Methods: A literature review on the impact of COVID 19 infection on the respiratory system, the cardiovascular system and the effect of physical strain on the course of the disease. Results: The impact of the COVID 19 infection on the respiratory system is considerable. The disease can be asymptomatic or with only mild symptoms, typically shortness of breath and cough. The main manifestation of a developed infection is bilateral covid pneumonia, which progresses to ARDS in approximately 20-30% of hospitalized patients. The impact of the disease on the cardiovascular system is increasingly debated. Sources describe elevation of troponin in the serum, as an indicator of myocardial damage, in up to 12% of all cases. It can manifest as myocarditis, arrhythmias, myocardial infarction, cardiogenic shock or even heart failure. The infection of COVID 19 is a multisystem...
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Experimental modelling of transport of inhaled fibrous particles in lungs
Varga, Michal ; Bělka, Miloslav (referee) ; Lízal, František (advisor)
Inhaled fibrous particles may either cause different potential diseases in our respiratory system or be used positively as drug carriers targeting specific parts of the respiratory system. To better understand their behaviour in both cases, either to assess their health risk or positive effects, precise knowledge of their movement behaviour in airways is needed. Since currently there isn’t much data describing the movement of fibrous particles in airways available, the goal of this thesis was to record their movement in the model of human trachea at the first bifurcation using a high-speed camera and breathing generator simulating real cyclic breathing patterns. Collected data were then processed and evaluated using five statistical tests. In the first three tests, the orientation of fibres to streamlines, possible flips from one orientation to another during their movement and the statistical significance of these events, were evaluated. In the fourth and fifth tests the length of fibre particles was evaluated.
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