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Functional movement disorders: pathophysiological mechanisms, diagnostic neurophysiological markers, and new therapeutic approaches
Slovák, Matěj ; Serranová, Tereza (advisor) ; Vevera, Jan (referee) ; Rusina, Robert (referee)
Functional movement disorders (FMD), previously referred as psychogenic, are characterized by inconsistency and incogruence with organic neurological disorders. The original psychological models of FMD were replaced by a neurobiological model of the disease. The identification of neurophysiological correlates of FMD and their comorbidities may add to the so far limited knowledge of the pathophysiology of these disorders. This Thesis focuses on three thematic areas of FMD: 1. assessment of prevalence of comorbid restless legs syndrome (RLS) and periodic limb movements (PLM) as an objective marker of RLS using actigraphy; 2. analysis of reflexive and volitional eye movements using videooculography (VOG); 3. evaluation of emotional arousal objectively by pupillometry and subjectively using affective ratings of emotional pictures. In total, 115 FMD patients and 76 age- and matched healthy controls participated in the studies. 1. FMD patients (N=96) presented with signficantly higher prevalence of RLS (43,8 % vs. 7,9 %, p<0,001) and clinically relevant PLM (20,8 % vs. 2,6 %, p=0,0002) compared to controls. The association of RLS/PLM with FMD raises the possibility of common pathophysiological mechanisms of these conditions and has clinical implications in management of FMD. 2. VOG analyses showed normal...
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: Kilian Seeber and his Contribution to the Development of
Baštanová, Petra ; Čeňková, Ivana (advisor) ; Šteffl, Jana (referee)
This MA thesis is a descriptive theoretical study dealing with the work of the conference interpreter, teacher and researcher Kilian Seeber. The thesis explores individual fields of interest of Kilian Seeber and the results of his research. It describes mainly the cognitive load in simultaneous interpreting, prosody and intonation, but also ethical decisions in simultaneous interpreting and issues connected with training of trainers. Furthermore, the thesis presents Seeber's teaching and interpreting projects and, last but not least, the reaction to his work and its reception in the international interpreting community. Key words: Kilian Seeber, cognitive load, eye tracking experiment, pupillometry, prosody, intonation, ethical decisions, simultaneous interpreting, blended learning.
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