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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Mechanisms of membrane protein quality control in the endoplasmic reticulum
 Jirout, Matěj ; Stříšovský, Kvido (advisor) ; Bařinka, Cyril (referee)
Integral membrane proteins (IMPs) undergo extensive quality control (QC) within the endoplasmic reticulum (ER) to maintain ER proteostasis and the integrity of the ER proteome. ER-associated ribosome quality control (ER-RQC) responds to ribosome stalls during translocation and helps "de-clog" blocked translocon. ER-associated degradation (ERAD) targets misfolded IMPs for proteasomal degradation. ERAD-resistant IMPs are degraded by different ER-phagic pathways, collectively referred to as ELRAD (ER-to-lysosome associated degradation). Coordination of these mechanisms is facilitated by the unfolded protein response (UPR), although UPR receptors are most likely not activated by aberrant IMPs, as all these mechanisms function in the QC of ER-luminal proteins.
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