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Polymeric particles for targeted drug delivery into mononuclear phagocytic system
Prošková, Denisa ; Holas, Ondřej (advisor) ; Šnejdrová, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Supervisor: PharmDr. Ondřej Holas, Ph.D. Consultant: Dmytro Iefremenko, M.Sc. Student: Denisa Prošková Title of Thesis: Polymeric paticles for targeted drug delivery into mononuclear fagocytic system Polymeric nanoparticles (NPs) can act as drug nanocarriers. They are frequently used to enhance distribution to a target tissues in which they specifically act. The mononuclear phagocytic system (MPS) represents a target to which NPs could be specifically distributed. It has been found that cells of this system are involved in the development of a number of diseases. Optimal parameters of NPs suitable for MPS targeting are size ranging between 100 nm and 300 nm and negative surface charge. In this work the polymeric nanoparticles with encapsulated cholic acid were prepared by nanoprecipitation method using five selected types of non-ionic surfactants in concentration of 0,1%, 0,5%, 1% and 2%. PLGA was the polymer used for their preparation because of its high biocompatibility and biodegradability. Encapsulation efficiency, size and zeta-potential were selected as critical parameters chosen for prepared nanoparticles. The obtained data were used to characterize the effect of non-ionic surfactants on the...
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Polymeric particles for targeted drug delivery into mononuclear phagocytic system
Prošková, Denisa ; Holas, Ondřej (advisor) ; Šnejdrová, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Supervisor: PharmDr. Ondřej Holas, Ph.D. Consultant: Dmytro Iefremenko, M.Sc. Student: Denisa Prošková Title of Thesis: Polymeric paticles for targeted drug delivery into mononuclear fagocytic system Polymeric nanoparticles (NPs) can act as drug nanocarriers. They are frequently used to enhance distribution to a target tissues in which they specifically act. The mononuclear phagocytic system (MPS) represents a target to which NPs could be specifically distributed. It has been found that cells of this system are involved in the development of a number of diseases. Optimal parameters of NPs suitable for MPS targeting are size ranging between 100 nm and 300 nm and negative surface charge. In this work the polymeric nanoparticles with encapsulated cholic acid were prepared by nanoprecipitation method using five selected types of non-ionic surfactants in concentration of 0,1%, 0,5%, 1% and 2%. PLGA was the polymer used for their preparation because of its high biocompatibility and biodegradability. Encapsulation efficiency, size and zeta-potential were selected as critical parameters chosen for prepared nanoparticles. The obtained data were used to characterize the effect of non-ionic surfactants on the...
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