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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Synthesis of new potential inhibitors of 5´-nucleotidases
 Šimák, Ondřej ; Pachl, Petr ; Brynda, Jiří ; Rosenberg, Ivan
The work deals with the synthesis of potential inhibitors of 5´-nucleotidases. The phosphonobenzylidene ring of a phosphonate nucleotide derivative was recognized as a target for proposed synthetic modifications. Substituents selected on the basis of a docking study, mostly the electronegative ones, should be suitable for the formation of additional hydrogen bonds, and thus the increased inhibition of the enzymes.
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From nucleoside phosphonic acids to modified oligonucleotides
 Rosenberg, Ivan ; Endová, Magdalena ; Králíková, Šárka ; Liboska, Radek ; Rejman, Dominik ; Točík, Zdeněk
A number of new isopolar phosphonate nucleotide analogues were prepared and a large set of oligonucleotides containing structurally diverse modification internucleotide linkages could be created.
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