|
|
Addictology services in the capital city of Prague with a focus on substitution treatment
Janyška, Jakub ; Šotolová, Eva (advisor) ; Mlčková, Marie (referee)
The thesis is devoted to the issue of addiction services with a focus on substitution treatment. Theoretical part focuses on presenting of susbstitution treatment, its history and description of the substitution substances and their effects on the human body. Describes the abuse of substitution treatment by problem drug users and tries to map out the various addiction treatment services with a focus on substitution treatment in Prague. The research section defines the attitude of society towards the establishment and functioning of Prague substitution centers. The thesis concludes with an overview of addiction services and substitution programs in the capital city of Prague. Powered by TCPDF (www.tcpdf.org)
|
|
|
Secondary and tertiary drug abuse prevention
Havlovičová, Kristina ; Šotolová, Eva (advisor) ; Mlčková, Marie (referee)
This bacelor work deals with the subjective perception of significance of substitution treatment by it's clients. It's aim is to find out, how the clients of this treatment perceive it's significance primarily in their lives. Out of the data gained from the research it is obvious that despite some negatives of the substitution treatment it's clients considers it to be very positive especially because it allows them to get involve in the society and to live the "normal life". Suprisingly, in comparison with the orientation of intact population the clients almost completely ignore the influence of substitution on their state of health and the risk of transer of infection diseases. Powered by TCPDF (www.tcpdf.org)
|
|
|
Fluorescently labeled ligands for the Mu-opioid receptors
Hadzima, Martin ; Machara, Aleš (advisor) ; Kohout, Michal (referee)
This Bachelor's thesis deals with preparation of fluorescently labeled opiates, which allow detection of µ-opioid receptors and study of their interaction with ligands, using fluorescent techniques. As substrates designated for chemical modifications were chosen semi-synthetic opiates, naloxone and naltrexone. Their conversion to corresponding C-6 hydrazones allowed further modifications of these substances and tracking, if any changes to their ability to interact with µ-opioid receptors ocurr. Firstly, known adducts of these hydrazones with fluorescein isothiocyanate were prepared. Then, we inserted linkers of different lengths between the opiate fragment and the fluorescent tag, systematically. Mentioned linkers were prepared from tetraethyleneglycole derivatives with aim to study binding constants of modified µ-opioid receptor ligands. In the end, we decided to prepare opiate conjugate with particular linkers of length corresponding, approximately, to decaethyleneglycole. Two different procedures were proposed for the preparation of this linker. One of them used click chemistry concept and the other was based on classic amide coupling. Both conjugates were converted to adducts with fluorescein to verify their specific binding to µ-opioid receptors. They were also provided to co-operating group,...
|
|
|
Addictology services in the capital city of Prague with a focus on substitution treatment
Janyška, Jakub ; Šotolová, Eva (advisor) ; Mlčková, Marie (referee)
The thesis is devoted to the issue of addiction services with a focus on substitution treatment. Theoretical part focuses on presenting of susbstitution treatment, its history and description of the substitution substances and their effects on the human body. Describes the abuse of substitution treatment by problem drug users and tries to map out the various addiction treatment services with a focus on substitution treatment in Prague. The research section defines the attitude of society towards the establishment and functioning of Prague substitution centers. The thesis concludes with an overview of addiction services and substitution programs in the capital city of Prague. Powered by TCPDF (www.tcpdf.org)
|
|
|
Secondary and tertiary drug abuse prevention
Havlovičová, Kristina ; Šotolová, Eva (advisor) ; Mlčková, Marie (referee)
This bacelor work deals with the subjective perception of significance of substitution treatment by it's clients. It's aim is to find out, how the clients of this treatment perceive it's significance primarily in their lives. Out of the data gained from the research it is obvious that despite some negatives of the substitution treatment it's clients considers it to be very positive especially because it allows them to get involve in the society and to live the "normal life". Suprisingly, in comparison with the orientation of intact population the clients almost completely ignore the influence of substitution on their state of health and the risk of transer of infection diseases. Powered by TCPDF (www.tcpdf.org)
|
|
|
Secondary and tertiary drug abuse prevention
Havlovičová, Kristina ; Šotolová, Eva (advisor) ; Mlčková, Marie (referee)
This bacelor work deals with the subjective perception of significance of substitution treatment by it's clients. It's aim is to find out, how the clients of this treatment perceive it's significance primarily in their lives. Out of the data gained from the research it is obvious that despite some negatives of the substitution treatment it's clients considers it to be very positive especially because it allows them to get involve in the society and to live the "normal life". Suprisingly, in comparison with the orientation of intact population the clients almost completely ignore the influence of substitution on their state of health and the risk of transer of infection diseases.
|
|
| |
|
|
Abuse of illegal drugs by student of University of South Bohemia
PLACHÁ, Markéta
The thesis research the frequency of illegal drugs use by student sof Univerzity of South Bohemia in the Czech Budějovice. In the theoretical part are characterized by drugs, illegal drugs and the effects of drug use on health, describes the emergence of drug addiction and its types and developmental stages of drug use. Furthermore, illegal drugs are divided into categories according to their effects and further described. The main aim of the practical part is the analysis of illegal drug use by students of the University of South Bohemia. On the basis of a questionnaire compiled data was found and it was statistically analyzed by the method, compares and conclusions were drawn. Over the past year have used an illegal drug 37.83% of respondents, that 2.91% of the respondents use illegal drugs daily. Earlier experience with illegal drugs has 18.78% of students of the University of South Bohemia. Past experience with drugs is more common in women, while use in the last year is much more common in men. The most commonly used substances are cannabinoids, as well as hallucinogens, opiates and finally stimulanci.
|
|
|
The Effectiveness of opiate substance treatment
Kourková, Zuzana ; Běláčková, Vendula (advisor) ; Říhová, Vladimíra (referee)
The thesis deals with a substance treatment of opiate addiction and determines drug abuse problems. The paper defines free and regulated market and describes drug prohibition compared with alcohol prohibition. The next part considers the theory of substitute and complement which is a basis for determination of a substance treatment. The goal of thesis is evaluating the effectiveness of substance treatment in the Czech Republic by force of cost-benefits analysis with current information. The empiric part is based upon the information about costs of substance treatment and about lost productivity. The effectiveness of substance treatment is confirmed, the amount gives after deductions for expenses an affirmative value. The next conclusion is positive appraisal of effectiveness of partial financing of Subutex, that is paid by consumer presently.
|
|
|
Safe Drug Handling In Medical Facilities.
MUSILOVÁ, Marie
Translation Czech ? English Abstract: Safe Drug Handling in Medical Facilities The issue of safety in drug handling in medical facilities creates a significant priority in maintaining and increasing the quality of care. The presented bachelor?s work deals with such problems both in theoretical and practical level. In the theoretical part it explains the methods of safe drug handling in all levels of that process, starting from the delivery of drugs from the hospital?s pharmacy, till their liquidation. In the research part it examines the knowledge level of the above problems of nurses in surgery or internal departments of a smaller, however an accredited hospital. The research has been outlined as a quantitative research through questioning ? a questionnaire. There were two objectives set up. Objective 1: To get an overall picture of the nurses? knowledge of handling, distributing and keeping drugs and Objective 2: To get an overall picture whether the nurses are acquainted with the principles of handling opiates. Both objectives have been fulfilled. Based on the objectives 8 hypotheses (H) have been set up: H 1: The nurses are acquainted with correct safeguarding of drugs ? confirmed; 96 percent of respondents master the principles of correct safeguarding of drugs. H 2: The nurses are acquainted with correct storing of drugs ? confirmed. 76 percent of them master the principles of correct storing. H 3: The nurses are acquainted with correct designation of drugs ? confirmed. 97 percent of them master the correct designation of drugs. H 4: The nurses are acquainted with the preparation of drugs ? confirmed. 88 percent of nurses master the correct preparation of drugs. H 5: The nurses are acquainted with the correct administration of drugs ? confirmed. 83 percent of nurses master the principles of correct drug administration. H 6: The nurses are acquainted with correct documentation maintenance when administrating drugs ? confirmed. 97 percent of respondents master the documentation agenda when handling drugs. H 7: The nurses are acquainted with the correct liquidation of drugs ? confirmed. 83 percent of nurses master the principles of correct liquidation of drugs. H 8: The nurses are acquainted with correct opiate handling ? confirmed. 94 percent of nurses are acquainted with the correct opiate handling. All 8 hypotheses have been confirmed. The results of the research will be granted to the Hospital in Pelhrimov, p. o., as a possible contribution to the continuous process of quality improvements. It is possible to find certain sections in the detailed text and the graphic part of the processing of answers to individual questions of the test, where the answers of nurses appeared slightly worse (although in total very good) and the proposal is to support training of employees, internal seminars and a creation of standards. The research presented the knowledge of a selected group of nurses in the Hospital in Pelhrimov, p.o., in the area of drug handling at a high level of quality. There is a possibility of further examination of possible mutual differences in the knowledge of the safe drug handling problems, between nurses in accredited and non-accredited health facilities.
|
guest ::
