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Searching adenine and guanine rich regions
Vlachynská, Alžběta ; Provazník, Ivo (referee) ; Maděránková, Denisa (advisor)
This work deals with searching adenine and guanine rich regions. Their finding which determines the randomness and functionality may lead to better understanding genetic data storage in DNA sequences. The first part of the work describes the chemical composition and structure of DNA, its replication, transcription and translation. It contains the basic information about the genome. The next chapter deals with numerical representation of DNA sequences, necessary for a computer processing. Nucleotide density is a method suitable for searching adenine and guanine rich regions. The practical part of the work is an application designed and implmented in MATLAB environment. The last part is the analysis of human, chimpanzee and mice genes.
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Nucleotide density for finding CpG islands
Sikorová, Eva ; Provazník, Ivo (referee) ; Maděránková, Denisa (advisor)
This bachelor thesis deals with searching for CpG islands in the DNA sequences using the nucleotide density vectors. The first part includes view of the DNA structure, the genetic information expression, more detailed analysis of CpG islands and primarily their detection methods. In the practical part the algorithm for graphical representation of nucleotides on the basis of their densities and detections of CpG islands of artificially created and real DNA sequences was realized in the MATLAB program. The thesis includes the analysis of twenty sequences with the expected content of CpGIs and the comparison of results between the created program and two search engines.
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Nucleotide density for finding CpG islands
Sikorová, Eva ; Provazník, Ivo (referee) ; Maděránková, Denisa (advisor)
This bachelor thesis deals with searching for CpG islands in the DNA sequences using the nucleotide density vectors. The first part includes view of the DNA structure, the genetic information expression, more detailed analysis of CpG islands and primarily their detection methods. In the practical part the algorithm for graphical representation of nucleotides on the basis of their densities and detections of CpG islands of artificially created and real DNA sequences was realized in the MATLAB program. The thesis includes the analysis of twenty sequences with the expected content of CpGIs and the comparison of results between the created program and two search engines.
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Searching adenine and guanine rich regions
Vlachynská, Alžběta ; Provazník, Ivo (referee) ; Maděránková, Denisa (advisor)
This work deals with searching adenine and guanine rich regions. Their finding which determines the randomness and functionality may lead to better understanding genetic data storage in DNA sequences. The first part of the work describes the chemical composition and structure of DNA, its replication, transcription and translation. It contains the basic information about the genome. The next chapter deals with numerical representation of DNA sequences, necessary for a computer processing. Nucleotide density is a method suitable for searching adenine and guanine rich regions. The practical part of the work is an application designed and implmented in MATLAB environment. The last part is the analysis of human, chimpanzee and mice genes.
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