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Designer drugs derived from phenethylamine in relation to the dopaminergic system
Leová, Mara ; Hejnová, Lucie (advisor) ; Lapka, Marek (referee)
The focus of this thesis is on designer drugs structurally derived from phenylethylamine, a trace amine that is a component of dopamine's structure and plays a crucial role in its functioning within the human organism. The dopaminergic system, in general, is vital for regulating mood, motivation, and, last but not least, the mechanisms of addiction. The ratio by which different substances affect the concentration of dopamine and serotonine in the synaptic cleft serves as a significant marker for determining the likelihood of developing addiction to a particular substance. The main body of this thesis comprises groups of phenylethylamine derivatives, their structural descriptions, metabolism, and their potential for abuse. Key words: dopamine, dopaminergic system, phenethylamine, designer drugs, novel psychoactive substances
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Acute effects of new psychoactive substance from the group of phenethylamine derivatives - an animal study
Syrová, Kateřina ; Šíchová, Klára (advisor) ; Svoboda, Jan (referee)
Synthetic N-methoxybenzyl ("NBOMe") phenylethylamine derivatives were developed as highly potent agonists for the research of 5-hydroxytryptamine receptors, however they have become available on the black market in the past few years. They are sought by recreational users as "legal LSD", in worse cases the replacement is unsuspected and these substances are a cause of serious intoxication with signs of serotonin toxicity. At this moment, there is very little data available, but their low price, easy access via the internet and legal status make these substances an interesting target for recreational users and a big challenge for scientists and for the lawmakers. 2CBFly-NBOMe belongs to this group. There is no information about its recreational use for now, but thiat is probably only a matter of time. The aim of this study is to determine acute effects of 2CBFly-NBOMe in Wistar rats. Active substance significantly reduced locomotor activity of the animals and caused higher anxiety, it also disrupted sensorimotor gating and lowered body temperature of animals. Pharmacokinetic profile was measured only in the blood serum, the highest concentrations of 2CBFly-NBOMe were detected 30-60 minutes after the administration of hallucinogen. This paper provides first information on the effect of 2CBFly-NBOMe on...
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Neurobiology and toxicity of new psychoactive substances from hallucinogens class
Zmátlo, Vít ; Leca, Nikola (advisor) ; Novotný, Jiří (referee)
Main focus of this thesis are the novel synthetic psychoactive substances from hallucinogens class. The first part expands the phenomenon of hallucinogens and describes its general mechanisms. Serotonergic system is emphasised with focus on 5-HT2A receptor as a main moderator of hallucinogenic aktivity. Next part enlightens the issue of new psychoactive substances and elaborates on two main classes of hallucinogens - tryptamines and phenylethylamines, with epmhasis on their synthetic derivates. There is described the form of occurence, relationship between chemical structure and biological activity, and current knowledge of neurobiology toxicity of those substances. Key words: New psychoactive substances, hallucinogens, serotonergic system, neurobiology, toxicity
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