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In vitro modulation of immune cells for adoptive cellular cancer immunotherapy
Kalkušová, Kateřina ; Smrž, Daniel (advisor) ; Kverka, Miloslav (referee)
Cancer is one of the leading causes of death in developed countries. Its traditional treatment is based on surgical removal of the tumor and metastases, radiotherapy, and chemotherapy. Recently, many new therapy options, including immunotherapy, have been investigated. Cancer immunotherapy seems to be a very promising treatment option as it has experienced many successes in the last few decades. However, there is still a number of patients not responding to today's immunotherapy methods. Adoptive cellular immunotherapy is one of those immunotherapeutic methods. This immunotherapeutic modality uses ex vivo prepared immune cells that participate in anti-tumor responses. Nowadays, most research is focused on the use of T cells, although many other cell types are considered, including dendritic cells. This thesis is focused on the modulation of dendritic cells for adoptive cellular cancer immunotherapy. The aim of the practical part is to evaluate the influence of beta2-microglobulin on the maturation of monocyte-derived dendritic cells. Key words: Adoptive cellular immunotherapy, dendritic cells, beta2-microglobulin, cancer
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