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The biological importance of CAS SH3 domain tyrosine phosphorylation
Janoštiak, Radoslav ; Brábek, Jan (advisor) ; Dvořák, Michal (referee)
Protein CAS is a major tyrosine-phosphorylated protein in cells transformed by v-crk and v-src oncogenes. It is a multidomain adaptor protein, which serves as a scaffold for assembly of signalling complexes which are important for migration and invasiveness of Src-transformed cells. A novel phosphorylation site in N-terminal SH3 domain was identified - tyrosine 12 located on binding surface of CAS SH3 domain. To study biological importance of tyrosine 12 phosphorylation, non-phosphorylable (Y12F) and phosphomimicking ( Y12E) mutant of CAS were prepared. We found that phosphomimicking mutation Y12E leads to decreased interaction of CAS SH domain with kinase FAK a phosphatase PTP-PEST and also reduce tyrosine phosphorylation of FAK. Using GFP-tagged CAS protein, we show that Y12E mutation caused delocalization of CAS from focal adhesion but has no effect on localization of CAS to podosome-type adhesion. Non-phosphorylable mutation Y12F cause hyperphosphorylation of CAS substrate domain and decrease turnover of focal adhesion and associated cell migration of mouse embryonal fibroblasts (MEFs) independent to integrin singalling. Analogically to migration, CAS Y12F decrease invasiveness of Src-transformed MEF. The results of this diploma thesis show that phosphorylation of Tyr12 in CAS SH3 domain is...
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Movements of migrants from Eastern metropolis in a globalizing world
Semkova, Martina ; Arnason, Johann Pall (advisor) ; Ezzeddine, Petra (referee)
This paper is focused on current trends in migration processes. The content is based on results of qualitative research, using the grounded theory method. This approach followed the movements of young migrants from Eastern Slovak city Košice, in different phases of development. Findings of the research were tied with relevant theories describing current processes, which are the results of intensive changes in society and create challenging environment for migration. Movements of migrants are directly connected to life perspectives and strategies in creating an optimal life conditions. The goal of the paper is to reveal behavioral similarities of migrant, in individualized and diversificated society, and to bring more comprehensive view of migration issue.
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Culturaly established ideas about legal and illegal migration
Kurucová, Alexandra ; Lupták Burzová, Petra (advisor) ; Jakoubek, Marek (referee)
Starting in 2015 European migration crisis very strongly influenced social discourse across the continent. A debate about migration crisis goes on not only in media, but it is also part of everyday lives and conversation among ordinary people. The goal of this master thesis was to identify culturaly established ideas about legal and illegal migration, immigration and immigrants at Czech and British students. A research was taking place in Czech Republic and Great Britain in- depth interviews, questions were also aimed at students' orientation in this issue, their ideas about immigrant integration or their view on xenophobic attitudes in society. The data obtained were analyzed by using the grounded theory and the result of this thesis is a theory drawn from them. Key words: students, migration, Great Britain, Czech Republic
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The formation of the Sikh diaspora in Great Britain
Ivanková, Bianka ; Štipl, Zdeněk (advisor) ; Bendíková, Soňa (referee)
The main objective of this bachelor thesis is to summarize and analyze the history of the migration of Sikhs to Great Britain from the mid 19th century to the end of the 20th century. It describes the forming process of one of the largest and most influential diasporas in British society. The thesis is divided into three main chapters. The first chapter will briefly overview the sikhism and its relantionship towards Indian government. The second chapter focuses on the general examination of indian diaspora, migration history from India to Great Britain, and finally it concentrates on the concept of diaspora and the possibility of its application to the British sikh community. The third chapter presents the main stages of sikh migration to the UK, starting with the first recorded immigrant, prince Duleep Singh, the period of the First World War up to the first wave of mass mmigration after 1945. Special attention is given to the arrival of sikh immigrants from East Africa in 1970s. The final part concerns about the impact of 1984 critical events in Punjab on British sikh society. Key words sikhism, Great Britain, diaspora, migration
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Approaches to the Hungarian minority in Slovakia in issues of minority education and the possibility of subsequent application in the working process
Dlábik, Ľubomír ; Irmanová, Eva (advisor) ; Balla, Petr (referee)
This diploma thesis clarifies the issue of Triadic nexus among Slovakia, Hungary and the Hungarian minority concerning education and economic access to areas inhabited by the Hungarian minority, which affect the graduates of minority schools in the Slovak labor market. At the same time it aspires to refer to this relationship as one of the factors that may impact on reduction in the number of members of the Hungarian minority in Slovakia. The main focus is on the trilateral approach to the issue of education in the Slovak minority schools in Hungarian language in case of teaching the state language. The consequences of the different trilateral relation approach to minority education can lead to inefficiency of minority schools teaching Slovak language, which can, in conjunction with the current economic approach of Slovakia to the areas inhabited by the Hungarian minority, lead to migratory pressures on graduates of minority schools as for the choice of university studies and their employability. The lack of language skills reduces their competitiveness and flexibility compared to linguistically better equipped individuals. The statistical data in education, employment and population movements that will be analyzed and compared, are freely available, and confirm this hypothesis.
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Approaches to the Hungarian minority in Slovakia in issues of minority education and the possibility of subsequent application in the working process
Dlábik, Ľubomír ; Irmanová, Eva (advisor) ; Balla, Petr (referee)
This diploma thesis clarifies the issue of Triadic nexus among Slovakia, Hungary and the Hungarian minority concerning education and economic access to areas inhabited by the Hungarian minority, which affect the graduates of minority schools in the Slovak labor market. At the same time it aspires to refer to this relationship as one of the factors that may impact on reduction in the number of members of the Hungarian minority in Slovakia. The main focus is on the trilateral approach to the issue of education in the Slovak minority schools in Hungarian language in case of teaching the state language. The consequences of the different trilateral relation approach to minority education can lead to inefficiency of minority schools teaching Slovak language, which can, in conjunction with the current economic approach of Slovakia to the areas inhabited by the Hungarian minority, lead to migratory pressures on graduates of minority schools as for the choice of university studies and their employability. The lack of language skills reduces their competitiveness and flexibility compared to linguistically better equipped individuals. The statistical data in education, employment and population movements that will be analyzed and compared, are freely available, and confirm this hypothesis.
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The migration-development nexus: Evidence from the Philippines
Hurajová, Lucia
This diploma thesis is aimed to investigate both theoretically and empirically the impact of migration on the development of the sending countries. It applies the "Three Rs" approach to examine how migrants can shape development reshape in their areas of origin via 3Rs: Recruitment, Remittances, and Return. Emphasis is put on remittances, the most visible aspect of international migration. In particular, regression analysis were carried out, using time series data over the period 1990-2014, to establish a relationship between remittances and development aspects such as economic and human development as well as comparing them with the effect of FDI and ODA. The findings indicate that migration through remittances play an influential role in the Philippines development but it comes at a price, too.
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Approaches to the Hungarian minority in Slovakia in issues of minority education and the possibility of subsequent application in the working process
Dlábik, Ľubomír ; Irmanová, Eva (advisor) ; Balla, Petr (referee)
This diploma thesis clarifies the issue of Triadic nexus among Slovakia, Hungary and the Hungarian minority concerning education and economic access to areas inhabited by the Hungarian minority, which affect the graduates of minority schools in the Slovak labor market. At the same time it aspires to refer to this relationship as one of the factors that may impact on reduction in the number of members of the Hungarian minority in Slovakia. The main focus is on the trilateral approach to the issue of education in the Slovak minority schools in Hungarian language in case of teaching the state language. The consequences of the different trilateral relation approach to minority education can lead to inefficiency of minority schools teaching Slovak language, which can, in conjunction with the current economic approach of Slovakia to the areas inhabited by the Hungarian minority, lead to migratory pressures on graduates of minority schools as for the choice of university studies and their employability. The lack of language skills reduces their competitiveness and flexibility compared to linguistically better equipped individuals. The statistical data in education, employment and population movements that will be analyzed and compared, are freely available, and confirm this hypothesis.
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The formation of the Sikh diaspora in Great Britain
Ivanková, Bianka ; Štipl, Zdeněk (advisor) ; Bendíková, Soňa (referee)
The main objective of this bachelor thesis is to summarize and analyze the history of the migration of Sikhs to Great Britain from the mid 19th century to the end of the 20th century. It describes the forming process of one of the largest and most influential diasporas in British society. The thesis is divided into three main chapters. The first chapter will briefly overview the sikhism and its relantionship towards Indian government. The second chapter focuses on the general examination of indian diaspora, migration history from India to Great Britain, and finally it concentrates on the concept of diaspora and the possibility of its application to the British sikh community. The third chapter presents the main stages of sikh migration to the UK, starting with the first recorded immigrant, prince Duleep Singh, the period of the First World War up to the first wave of mass mmigration after 1945. Special attention is given to the arrival of sikh immigrants from East Africa in 1970s. The final part concerns about the impact of 1984 critical events in Punjab on British sikh society. Key words sikhism, Great Britain, diaspora, migration
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Culturaly established ideas about legal and illegal migration
Kurucová, Alexandra ; Lupták Burzová, Petra (advisor) ; Jakoubek, Marek (referee)
Starting in 2015 European migration crisis very strongly influenced social discourse across the continent. A debate about migration crisis goes on not only in media, but it is also part of everyday lives and conversation among ordinary people. The goal of this master thesis was to identify culturaly established ideas about legal and illegal migration, immigration and immigrants at Czech and British students. A research was taking place in Czech Republic and Great Britain in- depth interviews, questions were also aimed at students' orientation in this issue, their ideas about immigrant integration or their view on xenophobic attitudes in society. The data obtained were analyzed by using the grounded theory and the result of this thesis is a theory drawn from them. Key words: students, migration, Great Britain, Czech Republic
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