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Retinal nerve fiber layer measurement in patients with Alzheimer's disease
Kasl, Zdeněk ; Jirásková, Naďa (advisor) ; Pašta, Jiří (referee) ; Skorkovská, Šárka (referee)
Retinal nerve fiber layer measurement in patients with Alzheimer's disease The current ophthalmologist's possibilities in diagnostics of Alzheimer's disease Alzheimer disease (AD) is the most common cause of dementia syndrome and mild cognitive impairment. To enroll the disease most securely there are used so called biomarkers using evidence of changed brain metabolism by pozitron emission tomography (PET) and in cerebrospinal fluid or the brain's structure magnetic resonance imaging (MRI). These methods are expensive, organisationally and temporally challenging and burdening for the patients. According to that reasons we are still seeking for alternative attitudes suitable for early diagnosis. The evaluation of thickness of retinal nerve fiber layer (RNFL) which is well accessible to examination through optical aparatus of the eye could be one of the options. The aim of our work was to present current knowledges about Alzheimer's disease targeting relations of Alzheimer's disease and an ophthalmological finding. In the next part of this paper we introduce the retinal nerve fiber layer measurement by optical coherence tomography (OCT) as a potential diagnostics method by screening of patients with Alzheimer's disease and to present our results measured in our cohort of patients. The studied cohort...
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Retinal nerve fiber layer measurement in patients with Alzheimer's disease
Kasl, Zdeněk ; Jirásková, Naďa (advisor) ; Pašta, Jiří (referee) ; Skorkovská, Šárka (referee)
Retinal nerve fiber layer measurement in patients with Alzheimer's disease The current ophthalmologist's possibilities in diagnostics of Alzheimer's disease Alzheimer disease (AD) is the most common cause of dementia syndrome and mild cognitive impairment. To enroll the disease most securely there are used so called biomarkers using evidence of changed brain metabolism by pozitron emission tomography (PET) and in cerebrospinal fluid or the brain's structure magnetic resonance imaging (MRI). These methods are expensive, organisationally and temporally challenging and burdening for the patients. According to that reasons we are still seeking for alternative attitudes suitable for early diagnosis. The evaluation of thickness of retinal nerve fiber layer (RNFL) which is well accessible to examination through optical aparatus of the eye could be one of the options. The aim of our work was to present current knowledges about Alzheimer's disease targeting relations of Alzheimer's disease and an ophthalmological finding. In the next part of this paper we introduce the retinal nerve fiber layer measurement by optical coherence tomography (OCT) as a potential diagnostics method by screening of patients with Alzheimer's disease and to present our results measured in our cohort of patients. The studied cohort...
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The detection of the first symptoms of Alzheimer's disease be the parient's close person.
Krynská, Martina ; Šiklová, Jiřina (advisor) ; Hamplová, Dana (referee) ; Dragomirecká, Eva (referee)
The dissertation thesis focuses on the topic of construction of new questionnaire, which is developed from four already existing questionnaires of activities of daily living. This new questionnaire summarizes strengths of those four and submits only those activities, which are affected at the early stage of Alzheimer's dementia. The topic is introduced in the broad context of social sciences, medical science and also submits the practical issues, considering effects of Alzheimer's disease to life of patient and his closest ones. New questionnaire, which is the result of empirical research, is based on correlation analysis of three commonly used screening cognitive tests and four questionnaires which evaluate activities of daily life, which are, used as best practice in the Counseling Center for Memory Disorders Clinic of Neurology of Faculty Hospital Kralovske Vinohrady in Prague. The research sample consists of patiens, who are affected with Alzheimer's disease already. That means, that the new questionnaire can be used as a tool for those, who are the patient's closest ones for purpose of screening and reviewing abilities of daily living over time. The questionnaire also presents comprehensively compiled a list of activities of daily living which Alzheimer's disease affects in early stage and this list...
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