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Biomarker detection using electrochemical method with microfluidic chip
Klepáčová, Ivana ; Svoboda, Ondřej (referee) ; Neužil, Pavel (advisor)
The thesis is focused on the development of the electrochemical system with microfluidic platform for the detection of multiple biomarkers. It analyses the use of biomarkers for the early diagnosis of cancer. The theoretical part contains basic information about voltammetric methods and microfluidic systems. The practical part provides solutions to the microfluidic chips, including the description of the used materials, designs, methodologies of preparation and conclusions from the testing of the manufactured microfluidic systems. The thesis describes the lock-in electrochemical system which measures the response of 4 electrochemical cells simultaneously. For the electrochemical system measurements, an electrochemical chip consisting of 64 electrochemical cells was used. The results of the analysis include the processing of the system tests and detected voltammetric curves of the Fe2+/Fe3+ solution and cysteine.
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Vector phase-sensitive measurement amplifier
Rejnuš, Milan ; Vlček, Čestmír (referee) ; Drexler, Petr (advisor)
The master’s thesis describes known methods of signal measurement using principle of synchronous detection. Various methods are presented, their principles are examined and the problems when using them are analyzed. Further, procedures for reduction of adverse effects are described also. Second part of this thesis is focused on the instrument design. The instrument is intended for detection and processing of the output signals in a given optometric system. The proposed device is designed to operate on the principle of synchronous detection method using a vector signal evaluation. Advantages and disadvantages are discussed below.
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Lock-in Amplifier
Pivnička, Martin ; Šír, Michal (referee) ; Beneš, Petr (advisor)
This thesis deals with coherent demodulation by using Lock-in amplifier. The first part of this thesis focuses on theoretical analysis of this issue. The second – practical part describes design, construction and measurement of single–channel and dual–channels analog Lock-in amplifier. Further is described measurement of flow through the Coriolis flow meter by using dual-channels Lock-in amplifier. As further is described design digital Lock-in amplifier by using measuring card. The conclusion summarizes the results of measurement of Lock-in amplifier.
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3 omega thermal conductivity measurements
Juračka, Matěj ; Bejček, Ludvík (referee) ; Beneš, Petr (advisor)
The goal of this semestral thesis is to describe theory of the thermal conductivity measurement with method 3 omega. This work explains principle of the 3 omega method. It also analyzes two type of resistance heaters – suspended wire and line heater on substrate (for different substrate). Work also explains measurement with method 3 omega, which includes description of the important measuring device lock-in amplifier.
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Measurement module based on electrochemical impedance spectroscopy intended for hydrogen fuel cell research
Přecechtěl, Vít ; Pazdera, Ivo (referee) ; Procházka, Petr (advisor)
This thesis deals with diagnostic fuel-cell parameters using electrochemical impedance spectroscopy. The document begins with brief explanation of fuel-cell operation and its basic principles. Thesis continues with description of fuel-cell voltage generation and influence of charge dual-layer on impedance. After that electrochemical impedance spectroscopy, signals used for perturbation and evaluation of impedance spectrum using Bode a Nyquist plot is described. Next part explains measurement of impedance spectrum using potentiostat in combination with lock-in amplifier or frequency response analyzer. Practical part of thesis is dedicated to electric circuit design of EIS module and software designed for automatic measurement of impedance spectrum. Last part shows results of EIS module testing.
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Phase Lock Amplifier
Fábik, Peter ; Havlíková, Marie (referee) ; Čejka, Miloslav (advisor)
The aim of the master thesis is on lock-in amplifiers. Amplifier's basic parts and lock-in circuits description is listed in introductory chapters. The thesis offers overview of parameters of chosen devices available on the market and their possible usage. We describe HF2LI device functions and usage of ziControl software. With the aim to verify properties of the device and ziControl software, one of the last chapters focuses on manipulation with HF2LI device. The conducted experiments and achieved results are presented in the last chapter.
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Design of measuring circuitry of gas sensor for very low limit detection measurement
Zwiener, Jan ; Pytlíček, Zdeněk (referee) ; Hubálek, Jaromír (advisor)
This thesis deals with various types of noise that affect measurement. With a special device called a lock-in amplifier, these interfering signals can be cancelled out so that the desired signal is well below the noise level. This device is described in the thesis and explains the principle of its operation. The thesis also deals with the application of this device to the device allowing the measurement of very small changes in resistance. The device is described in several functional blocks, each block is described in detail, to understand its function in the overall circuit. Part of the thesis is the creation of the proposed device and its practical verification, which is realized by measuring the device.
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Design of measuring circuitry of gas sensor for very low limit detection measurement
Zwiener, Jan ; Pytlíček, Zdeněk (referee) ; Hubálek, Jaromír (advisor)
This thesis deals with various types of noise that affect measurement. With a special device called a lock-in amplifier, these interfering signals can be cancelled out so that the desired signal is well below the noise level. This device is described in the thesis and explains the principle of its operation. The thesis also deals with the application of this device to the device allowing the measurement of very small changes in resistance. The device is described in several functional blocks, each block is described in detail, to understand its function in the overall circuit. Part of the thesis is the creation of the proposed device and its practical verification, which is realized by measuring the device.
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Biomarker detection using electrochemical method with microfluidic chip
Klepáčová, Ivana ; Svoboda, Ondřej (referee) ; Neužil, Pavel (advisor)
The thesis is focused on the development of the electrochemical system with microfluidic platform for the detection of multiple biomarkers. It analyses the use of biomarkers for the early diagnosis of cancer. The theoretical part contains basic information about voltammetric methods and microfluidic systems. The practical part provides solutions to the microfluidic chips, including the description of the used materials, designs, methodologies of preparation and conclusions from the testing of the manufactured microfluidic systems. The thesis describes the lock-in electrochemical system which measures the response of 4 electrochemical cells simultaneously. For the electrochemical system measurements, an electrochemical chip consisting of 64 electrochemical cells was used. The results of the analysis include the processing of the system tests and detected voltammetric curves of the Fe2+/Fe3+ solution and cysteine.
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3 omega thermal conductivity measurements
Juračka, Matěj ; Bejček, Ludvík (referee) ; Beneš, Petr (advisor)
The goal of this semestral thesis is to describe theory of the thermal conductivity measurement with method 3 omega. This work explains principle of the 3 omega method. It also analyzes two type of resistance heaters – suspended wire and line heater on substrate (for different substrate). Work also explains measurement with method 3 omega, which includes description of the important measuring device lock-in amplifier.
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