National Repository of Grey Literature 35 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
The influence of thyroid hormones and adrenal glands on mental function
Augustinová, Jana ; Šivicová, Gabriela (advisor) ; Špinka, Marek (referee)
This thesis focuses on effects of thyroid and adrenal hormones on mental functions, especially on cognitive functions and emotions. In the case of adrenal hormones it will also focus on stress and burnout syndrome, which are not considered as mental functions, but are connected to both psyche and the above mentioned hormones. The text is divided into two parts. The first, theoretical part deals with the anatomy and histology of these two organs, hormones that they produce and their influence on overall physical condition and pathology. The main section of this theoretical part deals with the description of influence of thyroid hormones and adrenal glands on the above mentioned mental functions. This work is based on both earlier and contemporary research, but predominantly on foreign research. In the second, empirical part, a proposal for longitudinal study of cortisol and thyroxine levels during depression treatment is presented. Klíčová slova: Hormones, thyroid glang, adrenal gland, mental functions, cognitive functions, emotions, stress, cortisol, thyroxine
Účinky rostlinných produktů na růst, stravitelnost, složení těla, imunitní a stresovou reakci u ryb
ZARE, Mahyar
The plant powders and extracts contain bioactive compounds, including phenolic compounds, proteins, vitamins, and minerals. These compounds have been shown to possess antistress, antiviral, antibacterial, and antifungal effects on fish. Nettle has been extensively studied in mammalian medicine, but its effects on aquaculture species have not been well documented. Recent studies have demonstrated the positive impact of nettle on the growth performance, hematology, blood biochemistry, immune system, and pathogens resistance of fish species. Nettle leaf powder at a rate of 30 g/kg feed, improved the final body weight (FBW), weight gain (WG), weight gain percent% (WG%), specific growth rate (SGR%), and increased whole-body proximate protein and ash content while reducing whole-body proximate fat rainbow trout (Oncorhynchus mykiss) fingerlings. Tarragon leaf powder at a rate of 30 g/kg feed, significantly increased the haematocrit% (Hct%) and leukocyte count. The combination of 10 g/kg feed nettle leaf powder and 10 g/kg feed tarragon leaf powder resulted in the highest levels of erythrocyte count and haemoglobin (Hb). Nettle leaf powder at 30 g/kg feed, tarragon leaf powder at 30 g/kg feed, and a combination of 10 g/kg feed nettle leaf powder and 10 g/kg feed tarragon leaf powder significantly increased albumin levels in blood serum. Tarragon leaf powder at 10 g/kg feed showed the highest blood serum lysozyme enzyme activity compared to the control. Blood serum total immunoglobulin and total protein levels were significantly associated with nettle leaf powder at 30 g/kg feed. The study confirms the positive effects of these additives on growth performance, whole body proximate composition, immunological, haematological, and selected blood serum biochemical factors. Different levels of garlic powder did not significantly affect growth performance and somatic indices in European perch (Perca fluviatilis). However, adding 30 g/kg feed garlic powder resulted in a significantly higher level of whole-body proximate protein. Both 10 g/kg feed and 30 g/kg feed garlic powder showed significantly higher fat digestibility than the control and 20 g/kg feed garlic powder groups. The 20 g/kg feed garlic powder diet resulted in significantly higher erythrocyte and leukocyte count. Furthermore, all garlic groups had significantly lower blood serum cholesterol levels compared to the control. Garlic powder at level 30 g/kg feed improved European perch's resistance against high density and net handling stress, as well as their haematological and immunological parameters. Immediately after stress, the level of cortisol in all garlic-fed groups was significantly higher than in the control group, and there was no significant difference in glucose levels among the groups. However, after 24 hours, the levels of both cortisol and glucose were lower in all garlic-fed groups compared to the control group significantly. Garlic powder at a level of 10 g/kg feed improved apparent fat digestibility, whole body proximate protein, hematological parameters, immunological parameters, and increased resistance in high density and net handling stress. Overall, garlic powder could be considered as a potential dietary supplement for managing stress in European perch, however, further research is needed to determine the optimal dosage and long-term effects. Results of present thesis suggest that the use of natural feed phyto-additives could be a potential solution to address health issues in aquaculture, leading to more sustainable and efficient food production.
The Importance of Circadian Rhythms in Humans with a Focus on Adolescents
Kolářová, Michaela ; Vančata, Václav (advisor) ; Ehler, Edvard (referee)
The aim of the presented diploma thesis is a detailed outline of the meaning of circadian rhythms in adolescence. Circadian rhythms appear in early childhood, but undergo many changes during lifetime. While in early childhood the waking and sleeping cycle shifts to an earlier time, during adolescence it is quite the opposite and the cycle is shifted a few hours later and in older age the cycle even returns to an earlier state. Adolescence is associated with the most significant changes and increased demands on study, independence and generally more overload at the expense of quality and adeqaute sleep, which not only causes circadian rhythms to dissipate and shift dramatically, which such as health. For adolescents, the delayed phase is naturally correlated with sexual development, with sleep patterns being controlled by the biological component. Respecting physiological changes in adolescence and striving for institutional changes seem to be the most appropriate therapies instead of forcing patterns basen on institutional and parental needs, which only undermines adolescent body chemistry, results in insufficient and poor quality sleep for functioning and healthy physiological development of adolescents.
Způsoby hodnocení stresu u koní
ČERNÁ, Michaela
This bachelor's thesis deals with the currently highly addressed issues in horse bree-ding, which is stress. It can be caused by a number of causes and lead to a number of undesirable consequences. These can adversely affect the health, performance or behavior of the animals. Therefore, this is a very important topic for horse breeders. The aim of this bachelor thesis was to write available current information about horse stress and select appropriate methods for its evaluation. The following proce-dures were chosen: heart rate, cortisol levels, body temperature and eye temperatu-re. The observation included 3 individuals who were integrated into the new herd. The most effective way to evaluate the degree of tremor in the incorporation of horses into a new herd was to measure the temperature of the eye using a thermal camera. Within 3 days, the value of the eye temperature dropped from 35.5 °C to 31.6 °C. An invasive and accurate method for determining stress in horses was found-free determination of blood cortisol concentrations, which were recorded at 64.3 nmol / l, 29.7 nmol / l when collected at 17:00 and 149 nmol / l when collected at 10:00. The morning time proved to be more suitable for blood collection to assess the degree of stress. Heart rate was recorded as normal (36 bpm, 44 bpm) and did not reflect the stress response. Rectal temperature measurement has proven difficult to perform in horses in a new environment and under stress. Eye temperature measurement proved to be the most accurate method for asses-sing stress in horses and blood cortisol levels, which is more suitable for scientific purposes. However, the goal of every breeder should be to try to prevent stressful situations, especially by fulfilling the welafre in horse breeding.
The Importance of Circadian Rhythms in Humans with a Focus on Adolescents
Kolářová, Michaela ; Vančata, Václav (advisor) ; Ehler, Edvard (referee)
The aim of the presented diploma thesis is a detailed outline of the meaning of circadian rhythms in adolescence. Circadian rhythms appear in early childhood, but undergo many changes during lifetime. While in early childhood the waking and sleeping cycle shifts to an earlier time, during adolescence it is quite the opposite and the cycle is shifted a few hours later and in older age the cycle even returns to an earlier state. Adolescence is associated with the most significant changes and increased demands on study, independence and generally more overload at the expense of quality and adeqaute sleep, which not only causes circadian rhythms to dissipate and shift dramatically, which such as health. For adolescents, the delayed phase is naturally correlated with sexual development, with sleep patterns being controlled by the biological component. Respecting physiological changes in adolescence and striving for institutional changes seem to be the most appropriate therapies instead of forcing patterns basen on institutional and parental needs, which only undermines adolescent body chemistry, results in insufficient and poor quality sleep for functioning and healthy physiological development of adolescents.
How doe's playing MMORPG influence mood of players
Kůra, Michal ; Lukavská, Kateřina (advisor) ; Hrabec, Ondřej (referee)
This bachelor thesis examines how doe's playing MMORPG game influences mood of the player. The main goal of research is to experimentaly verify if there is some mood boost caused by playing MMORPG game. This possible effect is examined via the BMIS questionnaire, which measures actual emotional state of player. BMIS questionnaires were administrated right before and after activity, to find out the difference caused by the activity. According to findings of this experiment playing MMORPG game significantly improves the mood, in comparison with watching documentary film. Some additional measures support the theory, that mood improvement during the game could be linked with development of the flow experience, which has, as some previous studies found out, higher probability to develop during playing MMORPG game then during other non-virtual leisure time activity such as watching documentary film.
Beneficial Effects of 11β-HSD1 Inhibition on Cognitive Performance in a Mouse Model of Alzheimer's Disease
Červinková, Tereza ; Červený, Lukáš (advisor) ; Musílek, Kamil (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Candidate: Tereza Červinková Supervisor: PharmDr. Lukáš Červený, Ph.D. Title: Beneficial Effects of 11β-HSD1 Inhibition on Cognitive Performance in a Mouse Model of Alzheimer's Disease The increased life expectancy goes hand in hand with ageing-related cognitive impairments. Alzheimer's disease (AD) is the most common type of dementia being an irreversible and progressive brain disorder with loss of cognitive functions. Recent studies suggest that excess of glucocorticoid (GC) action exerts deleterious effects on the hippocampus and causes impaired spatialmemory. In addition, it has been demonstrated that aged mice with cognitive deficits show increased gene expression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in the hippocampus and parietal cortex. The Senescence-Accelerated Mouse Prone 8 (SAMP8) strain is a spontaneous animal model of accelerated ageing. Many studies indicate that SAMP8 harbour the behavioural and histopathological signatures of AD. In the present study, we evaluated the neuroprotective effects of 11β-HSD1 inhibition by a potent pyrrolidine-based compound RL-118 and/or effects of diet on cognitive performance in different groups of SAMP8 by conducting behavioural and...
Beneficial Effects of 11β-HSD1 Inhibition on Cognitive Performance in a Mouse Model of Alzheimer's Disease
Červinková, Tereza ; Červený, Lukáš (advisor) ; Musílek, Kamil (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Candidate: Tereza Červinková Supervisor: PharmDr. Lukáš Červený, Ph.D. Title: Beneficial Effects of 11β-HSD1 Inhibition on Cognitive Performance in a Mouse Model of Alzheimer's Disease The increased life expectancy goes hand in hand with ageing-related cognitive impairments. Alzheimer's disease (AD) is the most common type of dementia being an irreversible and progressive brain disorder with loss of cognitive functions. Recent studies suggest that excess of glucocorticoid (GC) action exerts deleterious effects on the hippocampus and causes impaired spatialmemory. In addition, it has been demonstrated that aged mice with cognitive deficits show increased gene expression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in the hippocampus and parietal cortex. The Senescence-Accelerated Mouse Prone 8 (SAMP8) strain is a spontaneous animal model of accelerated ageing. Many studies indicate that SAMP8 harbour the behavioural and histopathological signatures of AD. In the present study, we evaluated the neuroprotective effects of 11β-HSD1 inhibition by a potent pyrrolidine-based compound RL-118 and/or effects of diet on cognitive performance in different groups of SAMP8 by conducting behavioural and...
Changes in Hormone Levels in Female Basketball Players and Their Relationship with Emotional state and Efficiency
Zikánová, Tereza ; Pivoňková, Věra (advisor) ; Hroníková, Linda (referee)
This thesis focuses on women's competition in female basketball players and their hormonal responses to winning and losing. We tested saliva samples of 29 female players for testosterone and cortisol which were collected in three phases: baseline samples, pregame samples and after game samples. In every collection phase we also inquired about the emotional state of mind of the respondents. Players completed a survey examining their subjective evaluation of the match result. We also used statistical data from every match, which provided an objective evidence on the players' usefulness. All the aforementioned variables were examined in relation to the testosterone and cortisol levels. The results have revealed that the cortisol levels are responsive to the match results, whereas the losing players display a significant rise of the stress hormone level after the match. The winners display only a slight increase in the cortisol levels. Testosterone levels did not prove to react to the match results. However, it was discovered that the winners exhibited higher levels of testosterone in all collection phases than their competitors. Nevertheless, the difference between the winners and the losers was not significant in any of the cases. The winners felt more positive after the match than the losers. The correlation...
Pineal lesions: clinical presentation, hormone secretion, sleep quality and effect of surgical treatment
Májovský, Martin ; Netuka, David (advisor) ; Šonka, Karel (referee) ; Lipina, Radim (referee)
Introduction: Pineal region is a deep-seated part of the brain surrounded by highly eloquent structures. Differential diagnosis of space-occupying lesions in this region encompasses pineal gland cysts, pineal gland tumours, metastases, germ cell tumours, meningiomas, gliomas, hemangioblastomas and neuroectodermal tumours. In this thesis, I focused mainly on patients with pineal cysts, which is a benign affection of the human pineal gland on the borderline between pathology and normality. The clinical management of patients with a pineal cyst remains controversial, especially when patients present with non-specific symptoms. A melatonin secretion in patients with a pineal cyst before and after a pineal cyst resection has not been studied yet and the effect of surgery on human metabolism is unknown. Materials and Methods: We performed a prospective study between 2000 and 2016. All patients with a pineal cyst larger than 7 mm were included. Epidemiological data, presenting symptoms, surgical results and radiographic and clinical follow-up were documented. We examined melatonin, cortisol and blood glucose secretion profiles perioperatively in a subgroup of 4 patients. The control group was represented by 3 asymptomatic patients with a pineal cyst. For each patient, 24-h circadian secretion curves of...

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