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Liposomal forms of drugs for the treatment of lung diseases caused by selected types of bacteria
 Janoušková, Vendula ; Smilek, Jiří (referee) ; Mravec, Filip (advisor)
This diploma thesis deals with the study of the encapsulation efficiency of the antibiotic doxycycline encapsulated in the individual liposomal systems depending on different composition of the components. We also discussed the kinetics of the encapsulated drug releasing from the carrier systems. The liposomal systems for the treatment of local lung diseases were selected due to their suitable physicochemical properties. The bacterium called Staphylococcus aureus was chosen as a model of the local lung disease, pulmonary pneumonia. Doxycycline was chosen as the antibiotic ideal for the treatment of staphylococcal infection. The aim of the diploma thesis was to optimize the composition of liposomes which would have application potential for the inhalation administration of drugs. Two suitable liposomal systems have been prepared consisting of the addition of various components as cholesterol and phosphatidic acid. We have succeeded in determination of the drug concentration for the encapsulation which had sufficient antimicrobial efficacy to treat the local lung disease. The cytotoxic tests were used to determine the side effects of selected liposomal systems. Furthermore, the individual liposomal systems were characterized in terms of size, zeta potential and kinetic stability which are other important properties effecting their future application potential.
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