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Rheological properties of silicone gels for scar treatment
Khorsand, Ghazal ; Šnejdrová, Eva (advisor) ; Paraskevopoulos, Georgios (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of Pharmaceutical Technology Supervisor: PharmDr. Eva Šnejdrová, Ph.D. Student: Ghazal Khorsand Title thesis: Rheological properties of silicone gels for scar treatment The thesis is focused on testing of the flow and viscoelastic properties of the scar treatment silicone-based gels, either commercially available or newly formulated gels under development. The theoretical part deals with the scar formation, silicone in scar treatment, and characterization of the gels. In the experimental part, rotational and oscillation tests were performed using a rotational rheometer. The obtained flow curves were fitted by Newton or Power law models. The shear viscosity, coefficient of consistency, and index of flow behaviour were used for gel characterization and comparison. The highest viscosity revealed in the ScarEsthetique cream, followed by RejuvaSil gel. Surprisingly, the Stratamed scar gel and Scar gel Dr. Max showed the lowest viscosity, even lower than the formulations at the development stage. Despite the name "gel", they behave as Newtonian fluids. The elastic modulus G', viscous modulus G'', and complex modulus G*, phase angle , the gel point, and linear viscoelastic region LVER were selected to describe the viscoelastic behaviour...
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Characterization of silicone scar treatment gels
Podzimková, Alena ; Šnejdrová, Eva (advisor) ; Miletín, Miroslav (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Author: Alena Podzimková Title of Thesis: Characterization of silicone scar treatment gels Supervisor: PharmDr. Eva Šnejdrová, Ph.D. This diploma thesis deals with characterization of silicone gels by various methods, specifically measurement of rheological properties, overall characterization of the composition by infrared spectroscopy, identification of volatile compounds by gas chromatography and determination of molecular weight distribution of polymers by gel permeation chromatography. The theoretical part provides information about scars and their treatment options and describes the principles and the evaluation of tests performed in the experimental part. Five commercial gels and three newly formulated scar healing gels were evaluated. Analysis of viscosity curves confirmed newtonian type of flow in commercial gels Scar Gel Dr. Max and Stratamed and in the newly formulated gels. Strataderm, RejuvaSil and ScarEsthetique show a decrease in viscosity under stress. Oscillation tests have shown a gel structure only with the commercial ScarEsthetique and RejuvaSil. Scar Gel Dr. Max, Strataderm, the newly formulated gels and Stratamed contain polymeric polydimethylsiloxane. In case of Scar...
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Characterization of silicone scar treatment gels
Podzimková, Alena ; Šnejdrová, Eva (advisor) ; Miletín, Miroslav (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Author: Alena Podzimková Title of Thesis: Characterization of silicone scar treatment gels Supervisor: PharmDr. Eva Šnejdrová, Ph.D. This diploma thesis deals with characterization of silicone gels by various methods, specifically measurement of rheological properties, overall characterization of the composition by infrared spectroscopy, identification of volatile compounds by gas chromatography and determination of molecular weight distribution of polymers by gel permeation chromatography. The theoretical part provides information about scars and their treatment options and describes the principles and the evaluation of tests performed in the experimental part. Five commercial gels and three newly formulated scar healing gels were evaluated. Analysis of viscosity curves confirmed newtonian type of flow in commercial gels Scar Gel Dr. Max and Stratamed and in the newly formulated gels. Strataderm, RejuvaSil and ScarEsthetique show a decrease in viscosity under stress. Oscillation tests have shown a gel structure only with the commercial ScarEsthetique and RejuvaSil. Scar Gel Dr. Max, Strataderm, the newly formulated gels and Stratamed contain polymeric polydimethylsiloxane. In case of Scar...
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