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Analysis of Historical Pharmaceutical Preparations of Caffeine and Santonin.
Nováková, Lucie ; Nesměrák, Karel (advisor) ; Červený, Václav (referee)
Historical pharmaceutical preparations of caffeine and santonin were analyzed by mass spectrometry, the sample of caffeine was quantified by spectrophotometry, the sample of santonin was quantified by acid-base titration. In the analyzed historical injection solution "Coffeinum natriosalicylicum" (dated circa 1945) was determined 110 ± 1 % of the declared amount of caffeine and 94.33 ± 0.02 % of the declared amount of sodium salicylate. There were observed neither degradation products of caffeine nor sodium salicylate. The content of santonin in the historical sample (dated prior 1918) was determined by titration to 104 ± 4 %, sample was pure santotnin with no additions. No degradation products of santonin was observed. The analyzed samples were stable for more than seventy, ninety resp., years of storage.
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Analysis of Historical Pharmaceutical Preparations of Naloxone, Adrenaline and Ephedrine.
Nováková, Lucie ; Nesměrák, Karel (advisor) ; Červený, Václav (referee)
The aim of the thesis was to analyze the historical pharmaceutical preparations, including the determination of the active substance and identify theirs possible degradation products. A historical pharmaceutical preparation of naloxone was analyzed by mass spectrometry. Historical pharmaceutical preparations of adrenaline and ephedrine were analyzed by UHPLC-MS and were quantified using a calibration curve. In the historical injection solution of naloxone, "NARCAN", dated around 1980, there were no significant degradation products and the measured mass and UV spectrum was consistent with the spectrum of naloxone. The analyzed sample of naloxone was stable even after 35 years of storage. In the analyzed historical injection solution of adrenaline, "Adrenalin Hydrochlor., Dr. Heisler" (dated between 1917 and 1938) was determined 5.26 ± 0.11 % of the declared amount of adrenaline. In the measured spectras were noticeable degradation products, which have not been described in the literature yet and their identification was beyond the scope of this paper. The analyzed sample of adrenaline was almost completely degraded during about ninety years. The stability test carried out with four standard solutions of adrenaline proved influence of oxygen, light, temperature and time on the degradation of adrenaline. In...
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Analysis of Historical Pharmaceutical Preparations of Caffeine and Santonin.
Nováková, Lucie ; Nesměrák, Karel (advisor) ; Červený, Václav (referee)
Historical pharmaceutical preparations of caffeine and santonin were analyzed by mass spectrometry, the sample of caffeine was quantified by spectrophotometry, the sample of santonin was quantified by acid-base titration. In the analyzed historical injection solution "Coffeinum natriosalicylicum" (dated circa 1945) was determined 110 ± 1 % of the declared amount of caffeine and 94.33 ± 0.02 % of the declared amount of sodium salicylate. There were observed neither degradation products of caffeine nor sodium salicylate. The content of santonin in the historical sample (dated prior 1918) was determined by titration to 104 ± 4 %, sample was pure santotnin with no additions. No degradation products of santonin was observed. The analyzed samples were stable for more than seventy, ninety resp., years of storage.
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