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Coeliac Disease and its Effect on Everyday Life
Hadravová, Petra ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
Coeliac disease is an autoimmune digestive disease that damages the villi of the small intestine and interferes with absorption of nutrients from food, and which is among the most common disease of the immune system. Essentially the body is attacking itself every time a person with coeliac consumes gluten. Currently is coeliac untreatable, the only treatment is a lifelong gluten free diet. Low public awareness and frequent late diagnosis usually causes unnecessary discomfort. For this reason are the most important aims of my work define basic knowledges about coeliac disease, symptoms, diagnosis and treatment. At the same time it should also provide an information, especially to general public about the effect of the disease on the quality of life.
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Coeliac Disease and its Effect on Everyday Life
Hadravová, Petra ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
Coeliac disease is an autoimmune digestive disease that damages the villi of the small intestine and interferes with absorption of nutrients from food, and which is among the most common disease of the immune system. Essentially the body is attacking itself every time a person with coeliac consumes gluten. Currently is coeliac untreatable, the only treatment is a lifelong gluten free diet. Low public awareness and frequent late diagnosis usually causes unnecessary discomfort. For this reason are the most important aims of my work define basic knowledges about coeliac disease, symptoms, diagnosis and treatment. At the same time it should also provide an information, especially to general public about the effect of the disease on the quality of life.
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HLA complex and association with autoimmune diseases
Karasová, Alexandra ; Slavčev, Antonij (advisor) ; Šírová, Milada (referee)
Autoimmune diseases are serious and sometimes life-threatening disorders that affect approximately 5 % of the world population and therefore represent a major socio-medical problem. The HLA complex is the best studied part of the human genome that encodes the HLA antigens, whose function is to present peptides to immune system (T-lymphocytes). During the study of the HLA complex it has been found that certain HLA antigens are strongly associated with the occurence of autoimmune diseases, despite the great progress in clarifying disease etiopathogenesis the mechanism of these associations is, however, not fully explained. Sometimes the association of autoimmune disease with the HLA complex is very strong, such as in ankylosing spondylitis or celiac disease, while in other diseases the association is relatively weak, suggesting a role of other genetic and / or environmental factors. The aim of this work is to briefly explain the structure and function of the HLA complex and its association with some severe autoimmune diseases.
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