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Progressive methods for waste water treatment
Doležalová, Adéla ; Konečná, Eva (referee) ; Vondra, Marek (advisor)
This bachelor thesis contains a description of progressive separation methods for wastewater treatment. It deals with the basic principles of separation methods, including membrane processes, sonolysis, ozonization, photolysis and photocoalysis. Their strengths and weaknesses are also described. Part of the thesis is also evaluation and comparison of individual technologies with regard to their practical applicability.
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PEGylated micelles for diagnostic and therapy against solid tumors
Hoang, Stéphane ; Hrubý, Martin (advisor) ; Frochot, Céline (referee) ; Bianco, Alberto (referee)
Title : PEGylated micelles for diagnostic and therapy against solid tumors. Keywords : micelles, ferrocene, photolysis, vectorization, nanoparticle, singlet oxygen Abstract : Nanomedicine is an emerging field that addresses the challenges faced by conventional medicine. The use of nanometric objects makes it possible to reduce side effects through targeted, specific treatment at reduced doses. Among these nanoparticles, micelles are widely exploited thanks to their small size and high modularity. As a result, their application extends to many fields, including oncology. Indeed, their size enables them to take full advantage of the characteristics of the tumor microenvironment, resulting in increased accumulation and retention of micelles in tumor tissue. Thus, the use of micelles as nanovectors offers a theranostic approach to cancer therapy. In this context, the work presented here is divided into two distinct parts. The first presents the synthesis and formulation of photodegradable PEGylated micelles capable of both generating cytotoxicity and delivering a hydrophobic molecule intracellularly. The second part focuses on the enhancement of the EPR effect by sonoporation, a method considered to be non-invasive. Results on murine models demonstrated the positive effect of this method by greatly improving...
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Progressive methods for waste water treatment
Doležalová, Adéla ; Konečná, Eva (referee) ; Vondra, Marek (advisor)
This bachelor thesis contains a description of progressive separation methods for wastewater treatment. It deals with the basic principles of separation methods, including membrane processes, sonolysis, ozonization, photolysis and photocoalysis. Their strengths and weaknesses are also described. Part of the thesis is also evaluation and comparison of individual technologies with regard to their practical applicability.
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Bilrubin - physicochemical properties and biochemical importance
Kupcová, Kristýna ; Hudeček, Jiří (advisor) ; Martínková, Markéta (referee)
This thesis briefly summarizes the literary data concerning bilirubin. In addititon to this, its experimental part is devoted to comparison of stability of bilirubin and its derivative, ranarubin, towards photolysis in aerobic conditions. The photolytic experiments were carried out at wavelength 366 nm for 4 hours. The resulting photolysates were characterised by absorption spectroscopy (400 - 800 nm) and mass spectrometry. The data obtained show a high degree of similarity for both compounds, which are both relatively stable against photolytic splitting and photooxidation to biliverdin.
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