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Mental development of children with low birth weight
Švandová, Lucie ; Ptáček, Radek (advisor) ; Fischer, Slavomil (referee) ; Myšková, Lucie (referee)
Introduction: There is a high prevalence of cognitive and socioemotional dysfunction and disorders in very low birth weight (VLBW <1500 g) and extremely low birth weight (ELBW <1000 g) children. These findings raise concerns and questions about the level of mental development of these children, not only in early childhood but also during school age, adolescence and adulthood. Methods: Socioemotional and cognitive development was assessed in 118 children with VLBW or ELBW and 101 children with normal birth weight (≥ 2 500 g), aged 5 to 9 years. The test battery contained selected subscales from the Intelligence and Development Scales (IDS) and the Developmental Neuropsychological Assessment - second edition (NEPSY-II). Parents were administered Behaviour Rating Inventory of Executive Function (BRIEF), and an anamnestic interview as well as observation was also conducted. Results: A statistically significant difference in cognitive and socioemotional development between children with VLBW/ELBW and children with normal birth weight. The IQ score of children with normal birth weight was on average 12.98 points higher. These children also perform better results than children with VLBW/ELBW in all subtests of the IDS and NEPSY-II. Parents did not evaluate impaired executive function. Conclusion: Among...
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The impact of IGF1 and selected IGF1 gene polymorphisms on postnatal growth in children SGA/IUGR and extremely preterm newborns.
Kytnarová, Jitka ; Zeman, Jiří (advisor) ; Baxová, Alice (referee) ; Houšťková, Hana (referee)
Long-term outcome of extremely preterm neonates depends on many endogenous and exogenous factors. Long-term follow-up of extremely preterm neonates during childhood and analyses of IGF1 gene polymorphisms may help to better understand the problems connected with delayed postnatal growth and the progression of cardiovascular diseases and diabetes mellitus type 2 in adulthood. The aim was the long-term follow-up of anthropometric parameters in children born at 22−25th and 26−27th week of gestation and to study the association between postnatal growth of extremely preterm children, children small for gestational age (SGA) and children born at term with appropriate birth weight/length (AGA) and IGF1 gene polymorphisms: (CA)10-24 repetitive polymorphism in promoter, microsatellite marker D12S318 and 185 bp in 3'UTR, (CT)n polymorphism (CA)n polymorphism 216 bp in the intron 2. Methods. 242 infants born at 22-27+6 weeks were enrolled. Anthropometric parameters were measured at the ages of 2 and 5 years in 72 children born at 22-25+6 week (group I) and 85 children born at 26-27+6 week (group II). Polymorphisms of IGF1 were analysed in 51 extremely preterm, 208 AGA and 59 SGA children using fragment analyses. The data of postnatal growth data in AGA children were obtained at 18 months, in SGA and extremely...
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The impact of IGF1 and selected IGF1 gene polymorphisms on postnatal growth in children SGA/IUGR and extremely preterm newborns.
Kytnarová, Jitka ; Zeman, Jiří (advisor) ; Baxová, Alice (referee) ; Houšťková, Hana (referee)
Long-term outcome of extremely preterm neonates depends on many endogenous and exogenous factors. Long-term follow-up of extremely preterm neonates during childhood and analyses of IGF1 gene polymorphisms may help to better understand the problems connected with delayed postnatal growth and the progression of cardiovascular diseases and diabetes mellitus type 2 in adulthood. The aim was the long-term follow-up of anthropometric parameters in children born at 22−25th and 26−27th week of gestation and to study the association between postnatal growth of extremely preterm children, children small for gestational age (SGA) and children born at term with appropriate birth weight/length (AGA) and IGF1 gene polymorphisms: (CA)10-24 repetitive polymorphism in promoter, microsatellite marker D12S318 and 185 bp in 3'UTR, (CT)n polymorphism (CA)n polymorphism 216 bp in the intron 2. Methods. 242 infants born at 22-27+6 weeks were enrolled. Anthropometric parameters were measured at the ages of 2 and 5 years in 72 children born at 22-25+6 week (group I) and 85 children born at 26-27+6 week (group II). Polymorphisms of IGF1 were analysed in 51 extremely preterm, 208 AGA and 59 SGA children using fragment analyses. The data of postnatal growth data in AGA children were obtained at 18 months, in SGA and extremely...
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