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Creation and evaluation of information resources in medicine
Janda, Aleš ; Kasal, Pavel (advisor) ; Hendl, Jan (referee) ; Mihál, Vladimír (referee) ; Sumerauer, David (referee)
A field covering generation and evaluation of the medical information is a broad one. During my doctoral studies I focused on medical information mainly using the evidence-based medicine (EBM) principles. This approach leads to the use of currently best available medical data in the treatment of patients. The EBM methodology might be classified into two basic groups: afferent and efferent one. The afferent part is focused on development of information resources whereas the efferent one promotes optimal use of these resources and a critical application of the retrieved facts. Due to practical reasons (to limit extent of the text) I concentrated in the thesis on only one field of my activity. The text deals mainly with afferent part of EBM, namely with formation of a qualitative and quantitative synthesis of knowledge through compilation of a systematic review and meta-analysis. Compilation of systematic reviews of prognostic markers is discussed in a detail. It is a field not appropriately covered in the Czech literature. The practical outcome documented in the thesis is a description of the systematic review of immunohistochemical prognostic markers in intracranial ependymomas that was created and published by our research team. Compilation of this systematic review and meta-analysis was one of the...
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Creation and evaluation of information resources in medicine
Janda, Aleš ; Kasal, Pavel (advisor) ; Hendl, Jan (referee) ; Mihál, Vladimír (referee) ; Sumerauer, David (referee)
A field covering generation and evaluation of the medical information is a broad one. During my doctoral studies I focused on medical information mainly using the evidence-based medicine (EBM) principles. This approach leads to the use of currently best available medical data in the treatment of patients. The EBM methodology might be classified into two basic groups: afferent and efferent one. The afferent part is focused on development of information resources whereas the efferent one promotes optimal use of these resources and a critical application of the retrieved facts. Due to practical reasons (to limit extent of the text) I concentrated in the thesis on only one field of my activity. The text deals mainly with afferent part of EBM, namely with formation of a qualitative and quantitative synthesis of knowledge through compilation of a systematic review and meta-analysis. Compilation of systematic reviews of prognostic markers is discussed in a detail. It is a field not appropriately covered in the Czech literature. The practical outcome documented in the thesis is a description of the systematic review of immunohistochemical prognostic markers in intracranial ependymomas that was created and published by our research team. Compilation of this systematic review and meta-analysis was one of the...
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