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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Diabetes mellitus, environmental and genetic risk factors
 Procházková, Iveta ; Hubáček, Jaroslav (advisor) ; Kovacs, Peter (referee)
Diabetes mellitus (DM) is globally widespread group of diseases characterised by increased blood glucose. There are several types, the most common is type 1 DM and type 2 DM. Multifactorial polygenic inheritance is typical for DM with exeption of couple monogenic forms. Type 1 DM is autoimmune form usually manifesting since childhood. Its manifestation is influenced mostly by HLA system genotype, but also by non-HLA genes together with environmental factors, amongst which nutrition of the children is predominant. Type 2 DM develops usually in adulthood. The development is influenced by obesity and lack of movement, but the individual sensitivity to type 2 DM is also genetically determined. Main genetic factors are variations in genes TCF7L2 and FTO as well as in genes coding cyclin dependent kinases.
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Barriers of Development in Ethiopia: Structural Conditions and Strategies for Adaptation
 Kuzmič, Michal ; Pavlík, Petr (advisor) ; Jeníček, Vladimír (referee)
The diploma thesis titled Barriers of Development in Ethiopia: Structural Conditions and Strategies for Adaptation is focused on analysis of environmental risk factors and their impact on economic development of Ethiopia. It further evaluates the effectiveness of concrete adaptation measures on both official policy level and community level. The thesis departs from refined version of Jared Diamond's five point framework for analysis of collapse of complex societies. Contemporary scholarly discourse of rapid population growth, deforestation & land degradation and climate variability is formalized into causal schemes and supported by current statistical data. The thesis concludes that adopted measures have had only limited effect on elimination of the respective risk factors. Thus, Ethiopia remains a long-term recipient of foreign humanitarian assistance, without which it would fall into state of economic collapse. To overcome this situation Ethiopia needs to transform its subsistence agricultural production system.
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