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The influence of metabolites and their parent phenolic compounds on blood platelets
Hrubša, Marcel ; Mladěnka, Přemysl (advisor) ; Moťovská, Zuzana (referee) ; Kollár, Peter (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmacology and Toxicology Candidate: Mgr. Marcel Hrubša Supervisor: Prof. PharmDr. Přemysl Mladěnka, Ph.D. Title of dissertation thesis: The influence of metabolites and their parent phenolic compounds on blood platelets Acute cardiovascular events (ACEs), such as stroke and acute coronary syndromes encompassing acute myocardial infarction, are one of the main causes of cardiovascular mortality in the world. Current pharmacotherapy focuses primarily on secondary prevention of their recurrence, where antiplatelet drugs play a key role. These drugs reduce platelet hyperreactivity, which is present in the majority of cardiovascular and metabolic diseases, and significantly decrease the risk of ACEs. However, the palette of currently available drugs faces many issues, such as resistance, high variability in both pharmacokinetics and pharmacodynamics, serious side effects and the route of administration. This thesis firstly briefly summarizes the current knowledge of platelet physiology along with available antiplatelet drugs and their mechanism of action. Second part of the theoretical introduction is dedicated to polyphenolic compounds, as polyphenol-rich diet is associated with many beneficial effects, particularly...
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The influence of metabolites and their parent phenolic compounds on blood platelets
Hrubša, Marcel ; Mladěnka, Přemysl (advisor) ; Moťovská, Zuzana (referee) ; Kollár, Peter (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmacology and Toxicology Candidate: Mgr. Marcel Hrubša Supervisor: Prof. PharmDr. Přemysl Mladěnka, Ph.D. Title of dissertation thesis: The influence of metabolites and their parent phenolic compounds on blood platelets Acute cardiovascular events (ACEs), such as stroke and acute coronary syndromes encompassing acute myocardial infarction, are one of the main causes of cardiovascular mortality in the world. Current pharmacotherapy focuses primarily on secondary prevention of their recurrence, where antiplatelet drugs play a key role. These drugs reduce platelet hyperreactivity, which is present in the majority of cardiovascular and metabolic diseases, and significantly decrease the risk of ACEs. However, the palette of currently available drugs faces many issues, such as resistance, high variability in both pharmacokinetics and pharmacodynamics, serious side effects and the route of administration. This thesis firstly briefly summarizes the current knowledge of platelet physiology along with available antiplatelet drugs and their mechanism of action. Second part of the theoretical introduction is dedicated to polyphenolic compounds, as polyphenol-rich diet is associated with many beneficial effects, particularly...
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The impact of compounds from cigarette smoke on blood coagulation in vitro
Afshari, Mohammadreza ; Carazo Fernández, Alejandro (advisor) ; Karlíčková, Jana (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Mohammadreza Afshari Supervisors: Pharm Dr Alejandro Carazo Fernández, Ph.D. Thesis title: The impact of compounds from cigarette smoke on blood coagulation in vitro Hemostasis is the physiological process that stops bleeding at the site of an injury while maintaining normal blood flow elsewhere in the circulation. It is characterized by the equilibrium between proteins, enzymes, and other biological factors. Hemostasis is one of the most important biological processes in our body and any alteration in the function can affect the health of the individual severely. Nowadays the world is experiencing an epidemy of cigarette smoking and many people are socially and economically affected by the health impact of cigarette smoking. Cigarette smoking has been proven to increase the chance of the development of various cardiovascular diseases such as atherosclerosis, coronary heart disease, stroke, and peripheral arterial disease, among others. Despite the large number of studies conducted on the effect of cigarette smoke on the cardiovascular system, there are only scarce studies that directly evaluate the effect and impact of cigarette smoke on the hemostasis and their effect on specific steps....
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