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National Repository of Grey Literature

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	Comparative study of Trichomonas vaginalis strains with various level of metronidazole resistance Havelka, Michal ; Tachezy, Jan (advisor) ; Kopáček, Petr (referee) Trichomonas vaginalis is an anaerobic protozoan that causes the human disease trichomoniasis. The most commonly used drug against trichomoniasis is metronidazole. Metronidazole is highly effective, yet in some cases T. vaginalis is resistant to this drug. In T. vaginalis, we distinguish resistance to metronidazole into two types based on the conditions in which it occurs, aerobic and anaerobic resistance. Both types of resistance are associated with changes in the physiology of the parasite. The aim of this study was to characterize the changes in hydrogenosome and cytosol associated with metronidazole resistance at the proteome level in aerobically resistant clinical isolates, the aerobically resistant line MR3 and the anaerobically resistant line MR100. A further aim of this work was to characterize the function of hybrid- cluster protein and to clarify its role in resistance to metronidazole since its production is more abundant in both aerobically and anaerobically resistant T. vaginalis. This work contributed to identification of several potential proteins that could play a role in the development of metronidazole resistance and established a foothold for further metabolomic and biochemical studies of metronidazole resistant T.vaginalis. Detailed record
	Poruchy funkce apoptosomové dráhy u nemalobuněčného karcinomu plic Křepela, Evžen ; Procházka, Jan ; Fakultní nemocnice Na Bulovce (Praha, Česko) Detailed record
	Význam sledování sérových a buněčných nádorových markérů pro diagnostiku a prognózu rakoviny prsu Karlíček, Václav ; Topolčan, Ondřej ; Fakultní nemocnice (Plzeň, Česko) Detailed record

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