National Repository of Grey Literature 6 records found  Search took 0.01 seconds. 
The influence of recombinant proteins from tick saliva on the activity of murine NK cells
BERÁNKOVÁ, Zuzana
The aim of this study was to investigate the influence of selected recombinant proteins (tick salivary cystatins) and tick saliva derived from Ixodes ricinus on the cytotoxic activity of murine NK cells in vitro. We determined the suppressive effect of tick saliva and two tick salivary cystatins on NK cell activity.
The effect of tick cystatins on TLR - induced maturation of myeloid dendritic cells
NERADOVÁ, Hana
Tick saliva contains a lot of molecules with antihemostatic and immunosupressive effects.The goal of this thesis is to test the effects of tick salivary cystatins from I.ricinus and I.scapularis on TLR - induced maturation of bone-marrow derived dendritic cells and production of chosen cytokines. Over all, the supressive effect of tick cystatins was observed in relation to TLR-induced maturation of DC. In addition, cystatins enhanced production of IL-10 and attenuated induction of IL-12 cytokines.
The influence of tick saliva on the replication of tick-borne encephalitis virus \kur{in vitro} and the influence of tick cystatins on gene expression of interferon regulated factors
ŠIRMAROVÁ, Jana
This study was focused on the influence of hard tick from Ixodes ricinus on the replication of tick-borne encephalitis virus in vivo and the on the accompained changes in the levels of inflammatory cytokines which were determined in serum of infected mice. Futher the effect of tick cystatins, the inhibitors of cysteine proteases, on gene expression of interferon regulated factors was investigated in dendritic cells upon stimulation with Toll-like receptor ligands.

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