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Role střevního prvoka \kur{Dientamoeba fragilis} v lidském zdraví a nemoci
KAŠPAROVÁ, Andrea
The main aim of this study was to summarize available information about the gut protist Dientamoeba fragilis with special focus on the influence of selected factors such as age, gender, travelling or lifestyle to its colonization. It was first described in 1918 by Jepps and Dobell. First, D. fragilis was classified as an amoeba but later, based on molecular studies, was revealed that it is closely related to the trichomonads. Dientamoeba fragilis has three life forms - cyst, precyst and trophozoite. Until recently, only trophozoite of D. fragilis stage was known and the way of transmission between individuals was not clear. Thus, it was hypothetised that D. fragilis trophozoites are transmitted with eggs of some worms colonizing gastrointestinal tract. Recently, the cyst and precyst stages were discovered. In addition to humans, the presence of D. fragilis has been observed in primates, pigs and some pets. Mice seem to be successful experimental models. In terms of age factor, D. fragilis is most common in young children. There have not been revealed any correlations between occurrence of D. fragilis and gender. Pathogenicity of D. fragilis is another controversial fact about this organism. In past, it was considered a pathogen causing gastrointestinal disorders, mainly in children. However, a few recent epidemiological studies focused on healthy human population highlighted that D. fragilis appears to be more common in people without no gastrointestinal problems. Despite of this, there is still a small number of epidemiological studies on people with no intestinal problems, thus, it is difficult to compare prevalence of D. fragilis between healthy populations and patients suffering from intestinal diseases. Occurrence of D. fragilis is more prevalent in developed countries in contrast to Western populations. RT-PCR was evaluated as the most optimal method of detection of this organism from stool samples. The role of this intestinal protist in health and disease remains the subject of scientific discussions. But according to some new studies this organism tends to commensal character in the human body. At the end of this theoretical work is a brief summary of the current experimental work, which will be presented in detail in the master thesis.
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Alzheimer's disabilities
Matoušová, Michaela ; Zemková, Jaroslava (advisor) ; Mužáková, Monika (referee)
This diploma thesis, "Alzheimer's disabilities ", deals with questions around people with Alzheimer's disabilities, which is the most common type of dementia. Alzheimer's disabilities is also very widespread in the population; and it is the 4th or 5th most common cause of death. The thesis is divided into two parts, the first part is theoretical and the second is empirical. In the theoretical part the thesis deals with the general characteristics of this disorder such as: causes, prevention, clinical manifestations, consequences, diagnostics and pharmacological approaches. The main focus of the theoretical part is in the second chapter, which deals with non-pharmacological approaches to people with Alzheimer's disabilities. In the empirical part, case studies on sufferers of Alzheimer's disabilities will be included. The empirical part focuses on substantive changes which occur in the lives of people with Alzheimer's disabilities, and whether these changes can be confirmed as being consequential of the affliction. Key words Dementia, Alzheimer's disabilities, clinical manifestation, non-pharmacological approaches.
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Alzheimer's disabilities
Matoušová, Michaela ; Zemková, Jaroslava (advisor) ; Mužáková, Monika (referee)
This diploma thesis, "Alzheimer's disabilities ", deals with questions around people with Alzheimer's disabilities, which is the most common type of dementia. Alzheimer's disabilities is also very widespread in the population; and it is the 4th or 5th most common cause of death. The thesis is divided into two parts, the first part is theoretical and the second is empirical. In the theoretical part the thesis deals with the general characteristics of this disorder such as: causes, prevention, clinical manifestations, consequences, diagnostics and pharmacological approaches. The main focus of the theoretical part is in the second chapter, which deals with non-pharmacological approaches to people with Alzheimer's disabilities. In the empirical part, case studies on sufferers of Alzheimer's disabilities will be included. The empirical part focuses on substantive changes which occur in the lives of people with Alzheimer's disabilities, and whether these changes can be confirmed as being consequential of the affliction. Key words Dementia, Alzheimer's disabilities, clinical manifestation, non-pharmacological approaches.
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