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National Repository of Grey Literature

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Measuring adherence in patients with oral targeted therapy in chronic lymphocytic leukaemia Hanusová, Barbora ; Malý, Josef (advisor) ; Kolmanová, Eliška (referee) Measuring adherence in patients with oral targeted therapy in chronic lymphocytic leukaemia Author: Barbora Hanusová Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Petra Rozsívalová Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Chronic lymphocytic leukaemia (CLL) is a hematological disorder characterized by clonal proliferation of mature B-cells. New oral targeted drugs have been used in clinical practice to treat CLL. The aim of this thesis was to measure adherence to oral targeted drugs, analyze pharmacotherapy and identify drug-related problems (DRP) and their management. Methods: The cross-sectional pilot study ran from September 2022 to March 2023 in University Hospital Hradec Králové. Patients ≥ 18 years old, with CLL diagnosis treated with ibrutinib, acalabrutinib or venetoclax were included. Medical data and pharmacotherapy were obtained using electronic medical records and patients' medication records. Guided interviews were performed to measure patients' adherence to oral targeted oncolytics using Czech version of The Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS-CZ) and determine their opinions about medicine using Czech translation of The Beliefs about Medicines... Detailed record

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