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Rheological properties of gelatin-based gels for ultrasound brain phantom
Bojňanská, Terézia Marianna ; Šnejdrová, Eva (advisor) ; Holas, Ondřej (referee)
CHARLES UNIVERSITY IN PRAGUE FACULTY OF PHARMACY IN HRADEC KRALOVE DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY Author: Terezia Marianna Bojnanska Supervisor: PharmDr. Eva Snejdrova, Ph.D. Title of diploma thesis: Rheological properties of gelatin-based gels for ultrasound brain phantom The diploma thesis deals with the evaluation of the viscoelastic properties of gelatin gels modified by addition of glutaraldehyde and glycerol using a rheometer with goal to verify the suitability of tested materials for their intended use as ultrasound brain phantoms. The theoretical part deals with gels in general and is focused on gelatin gels as a possible basic component of ultrasound phantoms, and the possibilities of characterizing gels as viscoelastic systems using methods of oscillatory rheometry. Gelatin gels of different concentrations (5; 7,5 and 10%) with the addition of glutaraldehyde and glycerol were characterized by complex modulus, complex viscosity, yield stress, phase angle. Temperature stability of the samples in the range from 20 to 50řC was tested. All tested gels were viscoelastic solids with a clearly defined linear-viscoelastic region, which is confirmed by phase angle values close to 0ř. With the increasing concentration of gelatin the values of the complex modulus increased, increasing...
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Rheological properties of agar-based gels for ultrasound brain phantom
Schneiderová, Marie ; Šnejdrová, Eva (advisor) ; Holas, Ondřej (referee)
CHARLES UNIVERSITY FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY Author: Marie Schneiderová Supervisor: Phar Dr Eva nejdrová Ph D Title of diploma thesis: Rheological properties of agar-based gels for ultrasound brain phantom The diploma thesis deals with the evaluation of the rheological properties of agar gels on a rotational rheometer. The theoretical section contains the characterization of gels, their distribution, properties and use in pharmacy, describes agar and its characteristic properties. It also provides brief information on phantoms and describes the agar-based phantom in more detail. The principles of oscillation tests and their evaluation are described. Twelve gels with different agar concentrations were tested: a series of gels without glycerol and a series of gels with glycerol. The structure of the gels was characterized by the test Evaluating product texture using oscillatory testing and te perature stability in the range of 20 ř C to 40 ř C by the Single frequency strain controlled temperature ramp test. The viscoelastic properties of pig brain tissue were characterized by the same tests. The gel structure was confirmed in all samples tested. The stiffness expressed by the value of the complex modulus G * increases with the agar concentration....
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