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Determination of selected drugs in water
Tran Xuan, Tiep ; Tulková, Tereza (referee) ; Vávrová, Milada (advisor)
Submitted thesis tackles the problem of numerous of antibiotics in waste water. Specifically, trimethroprim azithromycin and clarithomycin. In all of those cases we are dealing with a massive ecological threat at hand, causing harm to the enviroment. To isolation the specific kind of antibiotics the method of SPE was chosen by prior consultation with the supervisor. The method of high performance liquid chromatography with mass spectrometry detection was deemed superrior for the pinpointing of the exact pharmaceuticals in waste watters. The waste waters in and out flow was observed for twelve days with the maintainance of all necessary procedures listed above at water treatment plants Brno-Modřice.
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Priority pharmaceutical micropollutants in the context of the Czech Republic and the Water Framework Directive draft
Stonawski, Eva ; Cajthaml, Tomáš (advisor) ; Klusoň, Petr (referee)
One of the major global environmental problems is the pollution by priority micropollutants. These are substances that can have a negative impact on the environment and human health even at relatively low concentrations. Their identification and subsequent regulation on an international level is essential for prevention of the negative effects of these substances. This thesis focused on the assessment of relevance of the proposal of Water Framework Directive in relation to pharmaceuticals and related substances in the context of the situation in the Czech Republic. The analysed input data comprised of results of data monitoring from the Vltava River Basin and information on the distribution of pharmaceuticals from the State Institute for Drug Control between years 2016 and 2022. The data was collected from two sampling points that are situated right before the confluence with the Elbe River. The average of the concentrations above the limit of quantification (LOQ) and without outliers was considered, thus creating a model considering the maximum contamination load. On the basis of this model and information about individual substances, the relevance of the draft WFD for the Czech Republic was assessed. The result of the monitoring showed that during the monitoring period, none of the NECs of the...
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Determination of selected drugs in water
Tran Xuan, Tiep ; Tulková, Tereza (referee) ; Vávrová, Milada (advisor)
Submitted thesis tackles the problem of numerous of antibiotics in waste water. Specifically, trimethroprim azithromycin and clarithomycin. In all of those cases we are dealing with a massive ecological threat at hand, causing harm to the enviroment. To isolation the specific kind of antibiotics the method of SPE was chosen by prior consultation with the supervisor. The method of high performance liquid chromatography with mass spectrometry detection was deemed superrior for the pinpointing of the exact pharmaceuticals in waste watters. The waste waters in and out flow was observed for twelve days with the maintainance of all necessary procedures listed above at water treatment plants Brno-Modřice.
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Seasonal evolution of antibiotic concentrations in the wastewater of STP České Budějovice
JANOŠÍK, David
The aim of the diploma thesis was to monitor seasonal concentration changes of 7 antibiotics norfloxacin, levofloxacin, ciprofloxacin, azithromycin, erythromycin, trimethoprim and sulfamethoxazole in wastewater influent and (cleaned) water effluent in the Sewage Treatment Plant (STP) České Budějovice. Time-proportional 24 hours pooled samples of wastewater were collected every month from March 2011 to February 2012 in the influent and effluent pof the STP. The concentrations of target compounds were determined by using in line SPE/LC-MS/MS analysis. The highest average concentration in the influent was detected in case of norfloxacin (0.563 microgram/l) and ciprofloxacin (0.406 microgram/l). The highest average concentration in the effluent was detected in the case of trimethoprim (0.255 microgram/l) and erythromycin (0.117 microgram/l). Higher concentration of antibiotics was measured in the colder periods of the year. It was connected with increased use of antibiotics and with less cleaning efficiency of the STP in this season. The highest removal efficiency was determined for norfloxacin and ciprofloxacin, the lowest for erythromycin. The influence of the season on the removal efficiency of antibiotics was found esp. for azithromycin,trimethoprim and sulfamethoxazole.
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