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	Possibilities of prediction and immunointervention in type 1 diabetes Sklenářová, Jana ; Štechová, Kateřina (advisor) ; Saudek, František (referee) ; Pavlínková, Gabriela (referee) Type 1 diabetes mellitus (T1D) is an organ-specific autoimmune disease characterised by autoimmune destruction of insulin-producing beta cells in the islets of Langerhans. It is a long-term process initiated months or even years prior to the clinical onset. The main role in the pathogenesis is played by T lymphocytes but other cell types are involved as well. The presence of autoantibodies in the circulation is typical even before the disease onset. Nowadays, intensive research is focused on finding individuals at risk and developing an effective prevention. During my postgraduate studies I was involved mainly in the research of T1D prediction and prevention. We investigated the relationship of established autoimmune markers - autoantibodies - and the cellular reactivity to GAD65 and IA2 autoantigens. We discovered that the reaction to autoantigens is very individual and it is influenced by the patient's autoantibody profile. These results could be relevant in planning antigen-specific immunointervention studies and improving their efficacy. We also made an attempt to improve specificity and sensitivity of a beta cell destruction marker (specifically demethylated DNA), which would enable better understanding of the beta cell decline and identification of individuals at risk of T1D development. In... Detailed record
	Intranasální vakcinace v prevenci autoimunitních onemocnění Fundová, Petra ; Tlaskalová, Helena ; Ústřední vojenská nemocnice (Praha, Česko) Detailed record
	Juvenilní lymfocytární thyreoiditis a současný výskyt infekce Helicobacter pylori Pomahačová, Renata ; Štechová, Kateřina ; Fakultní nemocnice (Plzeň, Česko) Detailed record
	Detekce anti-inzulární T buněčné odpovědi u pacientů s diabetem 1. typu a u jejich prvostupňových příbuzných Štechová, Kateřina ; Saudek, František ; Univerzita Karlova. Detailed record
	Prevence IDDM BCG vakcínou: Lidský model přirozené vnímavosti/rezistence na infekci Mycobacterium bovis BCG Weigl, Evžen ; Hajdúch, Marián ; Fakultní nemocnice (Olomouc, Česko) Detailed record

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